We surveyed zoochorous seedlings at an urbanized site on Guam with a remnant population of frugivores, and otherwise similar lacking all frugivores. Both seedling richness abundance were much higher the providing hope that small populations can retain or restore ecological function. In tifong todu i dinekko’ gi unu na lug?t annai tåya’ Såli yan otro nu kulan acháparehu ya guaha siha. sedda’ lám...

•A conformation-adaptive fluorophore is reversibly modulated in [2]catenanes•The mechanically interlocked structure enables a robust fluorescent molecular switch•Two modulation modes, including wavelength and intensity, can be programmed Developing systems with tunability plays an important role many practical applications such as sensors, photo-electric devices, imaging, display devices. Learn...

•Six2Y129 site was dephosphorylated by phosphatase Eya1 in injured DA cells•Dephosphorylated Six2 translocated from cytoplasm to nucleus•Dephosphorylated protected cells down-regulating Tead1 expression Parkinson’s disease (PD) is a neurodegenerative characterized selective loss of dopaminergic (DA) neurons the substantia nigra pars compacta (SNpc). We recently reported that could reverse degen...

•Detecting pathogenic variants in VNTRs is challenging due to poor read mappability•VNtyper detects VNTR the MUC1 gene using Kestrel algorithm•VNtyper improves ADTKD-MUC1 diagnosis by accurate genotyping of coding VNTR•Integration VNtyper with SRS panel testing identified new overlooked patients The human genome comprises approximately 3% tandem repeats variable length (VNTR), a few which have ...

•We propose a chemical wire architecture for distributed biological computation•Our model predicts how input signals can be restored or modulated in the output•Chemical wires store temporal information and system act as timer•Digital periodic filtered by altering strain ratios Processing time-dependent requires cells to quantify duration of past regulatory events program time span future signal...

Pathogenic microorganisms often reside in glycan-based biofilms. Concentration and chain length distribution of these mostly anionic exopolysaccharides (EPS) determine the overall biophysical properties a biofilm result highly viscous environment. Bacterial communities regulate this state via intracellular small-molecule signaling to initiate EPS synthesis. Reorganization or degradation glycan ...

Diagnosis is essential for the management and treatment of patients with rare diseases. In a group patients, genetic study identifies variants uncertain significance or inconsistent phenotype; therefore, it urgent to develop novel strategies reach definitive diagnosis. Herein, we in-house Translational Diagnostics Program (TDP) validate as part diagnostic process close collaboration physicians,...

With the information of the complete DNA sequence of several higher eukaryotes as well as expression patterns of thousands of genes under a variety of conditions in our hands, we now have the possibility to computationally identify and analyze the parts of a genome believed to be largely responsible for transcription control { the promoters. This article gives a short overview of the state-of-t...

Evidence is mixed regarding the trajectory of emerging adults’ psychological profiles. While most research has shown an upward trend in psychological health, other research suggests that some emerging adults experience serious mental health problems. Ambiguity surrounding the research could be tied, at least in part, to study methods. I sought to examine the variability in emerging adults’ psyc...

In this paper we suggest to use the B formal method to model a protocol dedicated to smart cards. We use a pragmatic approach to prove the dynamic properties of the protocol by using historical variables to express the past. We check manually that those variables have been correctly updated in the different operations. With this approach we can avoid the use of a model checker to verify the dyn...