نتایج جستجو برای: refractory anemia
تعداد نتایج: 111788 فیلتر نتایج به سال:
Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits alo...
Warm autoimmune hemolytic anemia (wAIHA) is the most common form of AIHA, with corticosteroids in first-line treatment resulting in a 60-80% response rate. Atypical wAIHA and IgG plus complement mediated disease have a higher treatment failure rate and higher recurrence rate. We report a case of severe wAIHA secondary to Waldenström macroglobulinemia with life threatening intravascular hemolysi...
linezolid (lzd), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. lzd can induce thrombocytopenia, anemia and leukocytopenia. currently, reports on pure red cell aplasia (prca) cases induced by lzd are relatively rare [4-7]. in this paper, we reported a patient with prca twice induced by lzd. a 37-year-old man was diagnosed with myelody...
Sudden failure of an occasional patient afflicted with Addison-Biermer's disease (Addisonian pernicious anemia) to respond to adequate amounts of purified liver extracts in the absence of factors known to interfere with a therapeutic response has been observed by us during the past few years in the Minneapolis General Hospital. The occurrence of a refractory state for no apparent reasons has al...
Dyskeratosis congenita and Fanconi’s anemia share impressive features in common: primary refractory pancytopenia; bone marrow hyperplasia (curtailed phase) and megaloblastosis, eventuating in severe hypoplasia of the marrow; cutaneous melanotic dyschromia; lacrimal duct blockage and a host of other minor abnormalities, in addition to mental retardation and generalized impairment of growth. Eval...
Since the fundamental defect in pernicious anemia is inadequate or absent secretion of gastric intrinsic factor (1), specific therapy with intrinsic factor would seem, logically, to be the preferred treatment. After the demonstration (2, 3) that desiccated hog stomach could substitute for human gastric juice to facilitate the absorption of vitamin B12 in man, many patients with pernicious anemi...
Celiac disease is associated with multiple extraintestinal presentations, including bone disease, endocrine disorders and neurological deficits. We report a 9 year old girl with celiac disease presenting with recurrent Guillain Barre syndrome (third episode). There was no other clinical manifestation except for refractory iron deficiency anemia. Molecular mimicry explaining the association betw...
A patient with tuberous sclerosis who displayed all the manifestations of the disease had severe and refractory anemia and rapidly progressed to renal failure. OOOOOOOOOOOOOOOOOOOOOO Received: August 6, 1996 Accepted: June 26, 1997 Guido Bellinghieri, MD Division of Nephrology, Policlinico Universitario Via Consolare Valeria I–98100 Messina (Italy) Tel. +39 9
Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte antigens on B lymphocytes, T lymphocytes, monocytes, and myeloid cells. In th...
The extent and importance of autoimmune mechanisms in myelodysplastic syndrome (MDS) and the role of immunosuppression in the treatment of this disease are not well defined. We report overrepresentation of HLA-DR2 and its serologic split HLA-DR15 in both MDS and aplastic anemia (AA). Four clinically and ethnically defined patient groups were analyzed. The HLA-DR15 antigen frequencies among Nort...
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