BACKGROUND Nitrogen may contribute to reperfusion injury. Some studies have shown that helium as a replacement for nitrogen in breathing gas (heliox) reduces cell necrosis after ischemia/reperfusion when used in a preconditioning fashion (intermittent heliox exposure). Our aim was to test whether heliox, breathed continuously throughout the ischemic and reperfusion periods, reduced necrosis and...

BACKGROUND The benefits of vessel recanalization in acute myocardial infarction (AMI) are limited by reperfusion damage. In animal models, adenosine limits reperfusion injury, reducing infarct size and improving ventricular function. The aim of this study was to evaluate the safety and feasibility of adenosine adjunct to primary PTCA in AMI. METHODS AND RESULTS Fifty-four AMI patients undergo...

BACKGROUND No-reflow (TIMI < 3) during primary PCI (PCI) for STEMI occurs in 11-41% of cases, indicates poor myocardial tissue perfusion, and is associated with a poor outcome. We aimed to determine predictors and 12 month outcomes of patients who developed no-reflow. METHODS We analysed the PCI database of The Canberra Hospital and identified 781 patients who underwent primary PCI during 200...

Intracoronary administration of drugs allows to achieve the fastest possible effect in interventional cardiology. This avoid all biological filters body and required concentration active substance at injection site. Also, given local action, systemic side effects are nearly absent.&#x0D; The aim. To study literature data leading countries world field intracoronary drug administration. analyze e...

OBJECTIVE To evaluate the combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after myocardial infarction. DESIGN Myocardial contrast echocardiography was performed in patients with acute myocardial infarction shortly after successful coronary reperfusion (TIMI 3 patency) by direct angioplasty. Collateral flow was assessed before coronary angioplast...

AbstractBackground: Angiographic no-reflow phenomenon, areduced coronary antegrade flow (TIMI grade <-2) withoutmechanical obstruction after recanalization, predicts poor LVfunctional recovery and survival in the early phase of STEMI.Although predisposing factors phenom-enon were investigated, there is little data about clinical andprocedural predictors this phenomenon.Aim Study: The aim study ...