this manuscript reviews the present knowledge related to folliculogenesis in sheep.folliculogenesis starts with formation of primordial follicles before birth, present as a pool containing a certain number of follicles. by the attainment of puberty, a group of follicles from that pool starts to grow, a process known as primordial follicle activation or recruitment. the number of growing primord...

background: the present study was conducted in order to evaluate the effects of bilateral uterine artery ligation (bual) on the ovarian follicular fate, and alterations in carbohydrate, lipid, lipase and serum levels of f9sh, lh, prolactin, estrogen and progesterone. methods: twenty-four mature female rabbits divided into two test and control-sham groups. the animals underwent ovariohystrectomy...

Physiologically, the size of the primordial follicle pool determines the reproductive lifespan of female mammals, while its establishment largely depends on a process of germline cyst breakdown during the perinatal period. The mechanisms regulating this process are poorly understood. Here we demonstrate that c-Jun amino-terminal kinase (JNK) signaling is crucial for germline cyst breakdown and ...

Terminal follicular dynamics and ovulation rates (OR) were compared in different local breeds after introducing fecundity genes of different origin. Crossbred ewes which were carriers (F+) or non-carriers (++) of Booroola (BFec) or Cambridge genes (CFec) were included: CambridgexCambridge (CC), CambridgexSuffolk (CS), CambridgexTexel (CT), BooroolaxTexel (BT) and BooroolaxGerman Mutton Merino (...

Localization of androgen receptor (AR) was investigated in ovarian follicles developing and undergoing atresia during pregnancy in the pig. Immunohistochemical staining was conducted on ovarian antral follicles isolated on different days of gestation: 10, 18, 32, 50, 70, and 90. Paraffin sections were also subjected to in situ DNA labeling. TUNEL staining revealed the presence of positive folli...

www.landesbioscience.com Cell Cycle 3245 The ovarian follicle reserve is maintained in a delicate state of homeostasis aimed at preserving the majority of follicles in a dormant state. Key regulatory factors in follicle activation and quiescence include the PI3K/PTEN/Akt signaling pathway in the oocyte, as well as external paracrine inhibitory factors such as antiMullerian hormone (AMH) (Fig. 1...

Alopecia areata is a common autoimmune disorder that targets hair follicles. Swarms of lymphocytes surround the basis of the follicles, inducing loss of pigmented terminal hair and subsequently inhibit further hair growth. Depending on the extent of involvement, alopecia areata can be associated with a dramatic reduction of quality of life. Currently, no targeted treatment option is available, ...

Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pathway components localize to the unique, germline structure known as the nuage. In this study, we su...