Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. They are usually presented as amorphous products, mainly obtained by two major different methods, for example, melting and solvent...

The microstructure and residual stresses of an AA6040 Al to AZ31B Mg friction stir weld are studied using scanning electron microscopy and X-ray diffraction. The complex material flow promoted by the friction stir welding process results in a fine grained structure in the stir zone of both materials due to dynamic/recovery recrystallization. The interface between the materials is characterized ...

The stability and thermal behaviour of two anhydrate phases and a new mixed water:DMSO solvate of Olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine) are studied by different methods: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Raman scattering (RS). Single crystal structural data for the latter phase are presented, confirming ...

piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. in the current research, using taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. the variables include type of solvent,...

Recrystallization, which can occur dynamically or statically, is an importantphenomenon causing microstructure changes in deformed metals and therefore affecting theproperties of the material. Even though extensive investigations have been carried out on thenumerical modeling of recrystallization, the literature lacks accurate recrystallization modelswhich are able to predict mi...

The purpose of this study was to assess the properties of resistant starch (RS) III prepared from elephant foot yam starch using pullulanase enzyme. Native and gelatinized starches were subjected to enzymatic hydrolysis (pullulanase, 40 U/g per 10h), autoclaved (121°C/30 min), stored under refrigeration (4°C/24h) and then lyophilized. After preparation of resistant starch III, the morphological...

Nucleation of recrystallization in deformed metals is discussed with a focus on how theories have been achieved from experimental investigations. Suggested nucleation mechanisms and potential sites are reviewed to gain an overall understanding the state-of-the-art. Limitations applied techniques followed by analysis newly invented non-destructive 3D challenged accepted which based 2D studies. F...

Distance function-based diffusion generated motion, a highly efficient numerical algorithm, is used to simulate a classical model of recrystallization in unprecedented detail and in physically relevant parameter regimes not attainable with many previous techniques. The algorithm represents interfaces implicitly and is closely related to the level set method. In particular, it allows for automat...

AZ91D and 8.5vol.% SiCp/AZ91D magnesium matrix composites were fabricated by a semi-solid extruded processing method, treated with solution aging heat treatment. The effects of SiCp on the microstructures alloy during recrystallization studied observing analyzing microstructure evolution extrusions treatments. results show that addition inhibits dynamic extrusion only 26% volume fraction recrys...

A distributed dynamic model was built using gPROMS 2.3.7 language for an integrated Process including a cogeneration system, a plate heat exchangers set and a salt recrystallization process. It was analyzed the effect of a simulated spray system model on the integrated process, by comparing the global performance of the system with and without sprays. Due to air drift issues, quasi-random time ...