C-reactive protein is postulated to embody an index that can reflect cardiovascular risk and can be used to independently predict major cardiovascular events and mortality. On the other hand, credible experimental data have become available that demonstrate the abundant presence of C-reactive protein in atherosclerotic lesions and, moreover, identify C-reactive protein as an initiator of severa...

Progressive DNA damage and worsening aneuploidy are associated with the development of highly aggressive CTCL. We immunostained MF skin lesions for phosphorylated double-strand break repair genes γH2AX 53BP1 phosphorylated/activated ATM (pATM) found that ongoing breaks were frequent within malignant T cells even in clinically stable lesions. IL-6, a product senescent cells, is second most expre...

Vitiligo is a depigmentation disorder that commonly found in the community. The causes of vitiligo are multifactorial such as genetic and environmental factors accompanied by presence non-specific specific immune system factors. Melanocytes main target exposed reactive oxygen species (ROS) during process melanogenesis. Such exposure can cause loss homeostasis cell death has implications for vit...

Aim: This report presents a case of fibroma with its clinical features, treatment, and diagnosis follow up period.Background: Fibroma is the lesion that occur in response to stimulus within oral cavity, may result aesthetic functional issues related mastication. Peripheral ossifying considered be reactive, non-neoplastic exhibit variant characteristics. article describes reactive gingiva treatm...

Joint pain or arthralgia is a common complaint among girls who have received immunization with the human papillomavirus (HPV) vaccine, but the pathogenesis of this disorder has not been completely understood. We report 2 cases of joint lesions after HPV vaccination. In one case, a 13-yearold patient showed transient arthropathy in the right wrist joint after the first dose of Gardasil® administ...

Mesothelial lesions pose considerable diagnostic challenges not only because benign tumours, reactive proliferations and malignant mesothelioma can mimic one another, but also because the morphological patterns displayed by malignant mesothelioma can simulate a variety of epithelial and non-epithelial malignancies. Immunohistochemical markers can aid in distinguishing epithelioid malignant meso...

We report a patient with general paresis, whose magnetic resonance image (MRI) showed a T2 high-intensity lesion in bilateral mesial temporal regions. Serum rapid plasma reagin test showed reactive at 64 dilutions and serum Treponema pallidum haemagglutination test was 1:20480. Cerebrospinal fluid analysis showed: RBC 111/mm3, WBC 8/mm3, Venereal Disease Research Laboratory reactive at 1 diluti...

MicroRNAs have been shown to effectively regulate gene expression at the translational level. Recently, we identified novel microRNAs that were upregulated in a mouse model of spinal cord injury. Among those, we have focused on microRNA 486, which directly represses NeuroD6 expression through a conserved sequence in its untranslated region. We correlated the overexpression of microRNA 486 in mo...

Mesothelial lesions pose considerable diagnostic challenges not only because benign tumours, reactive proliferations and malignant mesothelioma can mimic one another, but also because the morphological patterns displayed by malignant mesothelioma can simulate a variety of epithelial and non-epithelial malignancies. Immunohistochemical markers can aid in distinguishing epithelioid malignant meso...

Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain barrier (BBB) and then across the astrocytic glia limitans (GL). Factors secreted by reactive astrocytes open the BBB by disrupting endothelial tight junctions (TJs), but the ...