Here we investigate the processes of accumulation and rotation in the generation of novelty by examining series generated by the accumulation of primes and approximations to the primes via progressive divisibility selections, and series generated by Riemann’s equation. Riemann’s zeta function is a re-encoding of the structure of the prime numbers. These studies indicate that the generation of p...

In this extended abstract we highlight ongoing work in developing procedural generation for the purposes of games. This research focusses on our recent development of a procedural generation framework developed in the EvoTanks domain, a re-imagining of the Atari 2600 title Combat. In addition, we highlight current work that utilises evolutionary algorithms not only to procedurally generate offe...

The usability of code generators in industrial modeling frameworks is frequently hindered by long re-generation time imposed by complex dependencies between different modules and chains of code generation phases. Incremental model transformation techniques may improve both scalability and usability by regenerating only specific design artifacts dependent on a specific change. In this paper, I p...

An object oriented data structure is presented for the purposes of finite element mesh generation. It is unique in the sense that it maintains containers of entities through an event m anager called reactable entities. This data structu re provides tight coupling with the geometric model (BRep) and user inputs to the mesh generation algorithms. It also provides a definition of a procedural clas...

Mechanisms underlying the genesis of re-entrant substrate for the most common cardiac arrhythmia, atrial fibrillation (AF), are not well understood. In this study, we develop a multi-scale three-dimensional computational model that integrates cellular electrophysiology of the left atrium (LA) and pulmonary veins (PVs) with the respective tissue geometry and fibre orientation. The latter is reco...

Endocytic transport necessitates the generation of membrane tubules and their subsequent fission to transport vesicles for sorting of cargo molecules. The endocytic recycling compartment, an array of tubular and vesicular membranes decorated by the Eps15 homology domain protein, EHD1, is responsible for receptor and lipid recycling to the plasma membrane. It has been proposed that EHD dimers bi...

Multinucleated Reed-Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL), and their presence is essential for diagnosis. How these giant tumor cells develop is controversial, however. It has been postulated that RS cells arise from mononucleated Hodgkin cells via endomitosis. Conversely, continuous single-cell tracking of HL cell lines by long-term time-lapse microscopy ha...

With the widespread deployment of broadband connections worldwide, software development and maintenance are increasingly being done by multiple engineers, often working around-theclock to maximize code churn rates. To ensure rapid quality assurance of such software, techniques such as “nightly/daily building and smoke testing” have become widespread since they often reveal bugs early in the sof...

We have used computational fluid dynamics to study changes in lift generation and vortex dynamics for Reynolds numbers (Re) between 8 and 128. The immersed boundary method was used to model a two-dimensional wing through one stroke cycle. We calculated lift and drag coefficients as a function of time and related changes in lift to the shedding or attachment of the leading and trailing edge vort...