BACKGROUND The inverse relationship between GLUT4 and RBP4 expression is known to play a role in the pathogenesis of type 2 diabetes. Elevated levels of RBP4 were shown to cause insulin resistance in muscles and liver. Identification of STRA6 as a cell surface receptor for RBP4 provides further link in this axis and hence we analyzed SNPs in these three genes for association with type 2 diabete...

retinol binding protein4 (rbp4) is a type of adipokine which transports vitamin a to serum. rbp4 could be a bridge between obesity and insulin resistance. this study aimed to investigate the effects of aerobic exercises on rbp4 serum's concentration and metabolic syndrome risk factors in obese women.twenty obese women with body max index 35.81±3.67kg/m2, fat percentage 43.98±4.02, and waist to ...

BACKGROUND Hepatitis E virus (HEV) is a major causative agent of acute clinical hepatitis in adults throughout much of Asia, the Middle East, and Africa. The lack of an efficient cell culture system for HEV has greatly limited our understanding of the mechanisms of infection, replication, and pathogenicity of this virus. The yeast two-hybridization system is considered to be an efficient method...

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum RBP4, TNF-alpha, insulin, C...

the aim of this study was to examine the effect of 12 weeks of concurrent training on rbp4 andinsulin resistance levels in obese middle-age men. for this purpose, 20 obese middle-age men voluntarily participated in this study and were assigned to concurrent training group (n=10, mean age 51.2 ± 2.25 yr and bmi 31.44 ± 0.81 kg/m²) and control group (n=10, mean age 50.3 ± 2.11 yr and bmi 30.32 ± ...

OBJECTIVE This study aimed to examine possible genetic effects of some retinol binding protein-4 (RBP4) single nucleotide polymorphisms (SNPs) on the risk of gestational diabetes mellitus (GDM). In addition, the SNPs were examined for their possible association with insulin resistance at 6 weeks after delivery. METHODS This was a prospective study of 100 women with GDM and 100 participants wi...

BACKGROUND Biological parameters are useful tools for understanding and monitoring complicated disease processes. In this study, we attempted to identify proteins associated with active pulmonary tuberculosis (TB) using a proteomic approach. METHODS To assess TB-associated changes in the composition of human proteins, whole blood supernatants were collected from patients with active TB and he...

Background: Type2 diabetes is a metabolic disease that is rapidly increasing in the world. GLUT4 and RBP4 are factors that play a role in glucose uptake. This study aimed to investigate the effect of moderate-intensity continuous training on RBP4 and GLUT4 gene expression of soleus muscle in STZ induced diabetic rats. Methods: This experimental study was conducted between May and September 201...