Several reports have indicated that the product of the retinoblastoma gene (Rb) complexes with the transcription factor E2F. We present evidence that the DNA-binding of the Rb-E2F complex involves another cellular factor. Addition of Rb to purified preparations of E2F does not generate an Rb-E2F complex that can bind DNA, and in fact, we see an inhibition of the DNA-binding ability of E2F. On t...

this paper presents a detailed small-signal and transient analysis of a full bridge pwm dc-dc converter designed for high voltage, high power applications using an average model. the derived model is implemented in a typical system and used to produce the small-signal and transient characteristics of the converter. results obtained in the analysis of the high voltage and high power design examp...

in this research, the total torque input and output shafts were subjected to are used to formulate twodifferential equations using applied dynamics and fluid mechanics. the equations show that the input andoutput torques are a function of the constant geometrical parameters of a torque converter, includinginternal and external diameters of vanes, angle and length of vanes, cross section area be...

MicroRNAs (miRNAs) play critical roles in retinoblastoma (RB) initiation and progression, aberrant expression of miR-145 had been frequently reported in cancer studies. However, the role and mechanism of its function in RB is still unclear. In this study, our data showed that miR-145 was downregulated in RB tissues and cell lines. Overexpression of miR-145 suppressed RB cell proliferation, migr...

In this study, participants were asked to identify briefly presented 5-letter (Experiments 1-3) or 2-letter (Experiment 4) strings. Identical items in a repeated trial were identified worse than their counterparts in a nonrepeated trial, indicating repetition blindness (RB; N. G. Kanwisher, 1987). In Experiment 1, RB occurred regardless of whether items were presented successively or simultaneo...

During neurogenesis, the progression from a progenitor cell to a differentiated neuron is believed to be unidirectional and irreversible. The Rb family of proteins (Rb, p107, and p130) regulates cell-cycle exit and differentiation during retinogenesis. Rb and p130 are redundantly expressed in the neurons of the inner nuclear layer (INL) of the retina. We have found that in the adult Rb;p130-def...

In this paper, a direct ac-to-dc power converter is proposed for efficient energy harvesting from the low voltage inertial micro generators. The conventional power converters use diode bridge rectifiers and condition the micro generator outputs in two stages. Hence, they are inefficient and may not be a feasible option for very low voltage micro generators. Moreover, they are not conducive for ...

Most mobile equipments use battery as power source. The increasing use of low voltage portable devices and growing requirements of functionalities embedded into such devices. Thus an efficient power management technique is needed for longer battery life for them. Given the highly variable nature of batteries systems often require supply voltages to be both higher and lower than the battery. Thi...

Oxygen top-blow converter is the main equipment in steelmaking. Because the support system of converter bears total weight of the converter and its accessories, and meanwhile transfers tilting torque from tilting mechanism to converter, it is the most important part of converter machinery. The joint equipment which links the converter with the support ring is the key part in the support system,...