A total of 1,734 adults performed two running memory tasks and a battery of cognitive tests representing four cognitive abilities. Simultaneous analyses were used to identify unique relations of each cognitive ability, including fluid intelligence, on the running memory measures. The large sample size allowed powerful analyses of the relations at the level of individual trials, separate list le...

This paper presents a method for object matching that uses local graphs called keygraphs instead of simple keypoints. A novel method to compare keygraphs was proposed in order to exploit their local structural information, producing better local matches. This speeds up an object matching pipeline, particularly using RANSAC, because each keygraph match contains enough information to produce a po...

The diversity of an organism's B- and T-cell repertoires is both clinically important and a key measure of immunological complexity. However, diversity is hard to estimate by current methods, because of inherent uncertainty in the number of B- and T-cell clones that will be missing from a blood or tissue sample by chance (the missing-species problem), inevitable sampling bias, and experimental ...

BACKGROUND Different preference-based measures (PBMs) used to estimate quality-adjusted life years (QALYs) provide different utility values for the same patient. Differences are expected since values have been obtained using different samples, valuation techniques, and descriptive systems. Previous studies have estimated the relationship between pairs of PBMs using patient self-reported data. H...

BACKGROUND The objective of this work was the study of analogical reasoning from the perspective of the equivalence-equivalence phenomenon. METHOD The variables studied consisted of the age of the participants and the educational level of the parents, in relation to performance on a reasoning task. The task utilized a sample size of 64 participants and an instrument based on conditional discr...

The scientific community's reliance on active-controlled trials is steadily increasing, as widespread agreement emerges concerning the role of these trials as viable alternatives to placebo trials. These trials present substantial challenges with regard to design and interpretation as their complexity increases, and the potential need for larger sample sizes impacts the cost and time variables ...

Noncompliance with study medications is an important issue in the design of endpoint clinical trials. Including noncompliant patient data in an intention-to-treat analysis could seriously decrease study power. Standard methods for calculating sample size account for noncompliance, but all assume that noncompliance is noninformative, i.e., that the risk of discontinuation is independent of the r...

Mediation models are widely used, and there are many tests of the mediated effect. One of the most common questions that researchers have when planning mediation studies is, "How many subjects do I need to achieve adequate power when testing for mediation?" This article presents the necessary sample sizes for six of the most common and the most recommended tests of mediation for various combina...

We obtain a tight distribution-specific characterization of the sample complexity of large-margin classification with L2 regularization: We introduce the γ-adapted-dimension, which is a simple function of the spectrum of a distribution’s covariance matrix, and show distribution-specific upper and lower bounds on the sample complexity, both governed by the γ-adapted-dimension of the source distr...

Our think tank tasked by the Dutch Health Council, consisting of Radboud University Nijmegen Honours Academy students with various backgrounds, investigated the implications of Deep Brain Stimulation (DBS) for psychiatric patients. During this investigation, a number of methodological, ethical and societal difficulties were identified. We consider these difficulties to be a reflection of a stil...