نتایج جستجو برای: ras
تعداد نتایج: 29876 فیلتر نتایج به سال:
زمینه و هدف: هدف از این مطالعه، مروری بر تحقیقات انجام یافته در زمینه وضعیت اکسیدان/ آنتی اکسیدانی در سرم و بزاق بیماران مبتلا به آفت راجعه دهانی (ras) بود. روش بررسی: با استفاده از واژه های کلیدی استوماتیت آفتی راجعه، آنتی اکسیدان، بزاق، هماتینیک و هماتینیک اسید، مقالات 10 سال گذشته و به طور عمده 3 سال اخیر (2010 تا 2013) استخراج شدند. از مجموع 37 مطالعه کلینیکی مورد بررسی، 18 مقاله موردی شا...
The gene-mutation-cancer hypothesis holds that mutated cellular protooncogenes, such as point-mutated proto-ras, "play a dominant part in cancer," because they are sufficient to transform transfected mouse cell lines in vitro [Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. & Watson, J. D. (1994) Molecular Biology of the Cell (Garland, New York)]. However, in cells transformed in vitro ...
Cholesterol-rich and caveolin-containing microdomains of the plasma membrane, termed "caveolae," have been implicated in signal transduction. However, the role of caveolae in regulating the Ras-MAP kinase cascade is incompletely understood. The mammalian Ras isoforms (H, N, and K) use different membrane anchors to attach to the plasma membrane and thereby may localize to functionally distinct m...
H-Ras and N-Ras become activated both at the plasma membrane and in endomembrane structures such as the Golgi apparatus. This compartmentalized activation is relevant from a signaling standpoint, because effector molecules can become activated differently depending on the region of the cell where Ras proteins are activated. An unsolved question in this new regulatory mechanism is the understand...
The Ras family of small GTPases (H-Ras, N-Ras and K-Ras) constitutes a central node in the transmission of mitogenic signals from cell surface receptors to the cell cycle machinery. In general, activation of membrane receptors causes GTP loading of Ras proteins via guanosine nucleotide exchange factor (GEF) stimulation. Loading of GTP promotes conformational changes that ultimately allow bindin...
BACKGROUND The small GTPase R-Ras displays a less potent transforming activity than the closely related Ras oncogene products. Although R-Ras has been reported to interact with c-Raf1 and Ral-GDS in vitro, the pathways by which it exerts its effects on cellular proliferation are not known. RESULTS Both Ras and R-Ras interact with phosphoinositide (PI) 3-kinase in vitro, and induce elevation o...
In this report, we examine how the Ras protein regulates neuronal survival, focusing on sympathetic neurons. Adenovirus-expressed constitutively activated Ras (RasV12) enhanced survival and the phosphorylation of Akt (protein kinase B) and MAP kinase (MAPK), two targets of Ras activity. Functional inhibition of endogenous Ras by adenovirus-expressed dominant-inhibitory Ras (N17Ras) decreased ne...
Posttranslational modification, in particular farnesylation, of Ras is crucial for activation of Saccharomyces cerevisiae adenylyl cyclase (CYR1). Based on the previous observation that association of CYR1 with cyclase-associated protein (CAP) is essential for its activation by posttranslationally modified Ras, we postulated that the associated CAP might contribute to the formation of a Ras-bin...
Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-defined surface pockets suitable for drug binding. Only recently, such pockets have been found in the c...
Progressive renal fibrosis is driven by a range of cytokines that act via membrane receptors and intracellular signaling cascades to evoke gene transcription events and related responses. The Ras family of GTPases has been implicated in many of these signaling cascades in model systems such as 3T3 fibroblasts. However, the roleof the specific Ras isoforms Ki, Ha, and N in the stimulation of ren...
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