1. Single units and evoked potentials were recorded in dorsal cochlear nucleus (DCN) in response to electrical stimulation of the somatosensory dorsal column and spinal trigeminal nuclei (together called MSN for medullary somatosensory nuclei) and for tactile somatosensory stimuli. Recordings were from paralyzed decerebrate cats. 2. DCN principal cells (type IV units) were strongly inhibited by...

[The NTP] had to be more responsive to critical issues in public health policy. Since its inception in 1978, the National Toxicology Program (NTP) has made considerable progress toward achieving its goal of international prominence based on excellence in toxicological studies. In the early 1990s when we first developed significant interactions with the NTP, we were struck by the reputation of t...

This paper presents a randomized parallel algorithm for the Maximal Independent Set problem. Our algorithm uses a BSP-like computer with p processors and requires that n+m p = (p) for a graph with n vertices and m edges. Under this scalability assumption, and after a prepro-cessing phase, it computes a maximal independent set after O(log p) communication rounds, with high probability, each roun...

This thesis deals with the following three independent problems. Pósa proved that if G is an n-vertex graph in which any two nonadjacent vertices have degree sum at least n + k, then G has a spanning cycle containing any specified family of disjoint paths with a total of k edges. We consider the analogous problem for a bipartite graph G with n vertices and parts of equal size. Let F be a subgra...

case studies to two children’s disorders that appear to have environmental etiologies but are less well understood: disorders of lipid and carbohydrate metabolism and attention deficit/ hyperactivity disorder (ADHD). A discussion will follow each case study presentation to consider the opportunities, the barriers and the design challenges that confront future clinical, toxicological, epidemiolo...

sarcoma. 4. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies. Int 7 Cancer 1981 ;28:469-74. 1' Emery AEH. Recombinant DNA technology. Lancet 1981;ii:1406-9. 12 Macnab GM, Alexander JJ, Lacatsas G, Bey EM, Urbanowicz JM. Hepatitis-B surface antigen produced by a human hepatoma cell line. BrJ Cancer 1976;34:507-15. 13 Edman JC, Gray P, Valenzuela P, Rall LB, Rutter WJ. Integration of hepa...

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions via the cAMP-dependent intracellular signal transduction pathways. Being the first second messenger described (Rall and Sutherland, 1958), cAMP has been ...

A wide variety of hormones, such as epinephrine, glucagon and ACTH, increase the intracellular concentration of cyclic AMP in several tissues and cyclic AMP induces simi lar effects to those of many hormones (1, 2). Thus it has been proposed that cyclic AMP mediates the responses of these hormones. Increased concentrations of cyclic AMP in tissues are caused by enhanced adenyl cyclase activity ...

Antidromic impulses travelling along a motor fibre can fail in invading the soma, due to their passing through neuronal regions characterised by non-uniform geometry and a reduced nerve conduction safety factor: the myelinated–unmyelinated junction, the axon–soma junction and profuse branching of dendrite terminals (Eccles, 1955). In particular, the axon–soma junction is clearly a non-uniform a...

1. Aims This section sets out to answer the second aim of this study, namely:-ii) To determine qualitatively and quantitatively the food eaten by that population,. The information presented in this section (unless otherwise stated) has been obtained from the Study Block (see Section II) by the methods described below. The previous section, which considered the population aspects, formed an esse...