نتایج جستجو برای: rag1

تعداد نتایج: 1083  

Journal: :Hematology/oncology and stem cell therapy 2014
Nivedita Dhingra Satya Prakash Yadav Jean-Pierre de Villartay Capucine Picard R K Sabharwal Veronique Dinand Samarjit Singh Ghuman Anupam Sachdeva

We describe an unusual case of severe combined immunodeficiency (SCID) with neutropenia and central nervous system (CNS) manifestations in which a novel RAG1 mutation was identified. A 15-month-old boy presented with failure to thrive, neutropenia and recurrent infections. He was diagnosed with T-B-NK+ SCID. He subsequently developed right partial seizures with ipsilateral hemiparesis and becam...

Journal: :Cell 2010
Yanhong Ji Wolfgang Resch Elizabeth Corbett Arito Yamane Rafael Casellas David G. Schatz

The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene segments, has not previously been characterized in vivo. Here, we demonstrate that RAG protein binding occurs in a highly focal manner to a small region of active chromatin encompassing Ig kappa and Tcr alpha J gene segments and Igh and Tcr beta...

Journal: :The EMBO journal 2004
Adam G W Matthews Sheryl K Elkin Marjorie A Oettinger

Following V(D)J cleavage, the newly liberated DNA signal ends can be either fused together into a signal joint or used as donor DNA in RAG-mediated transposition. We find that both V(D)J cleavage and release of flanking coding DNA occur before the target capture step of transposition can proceed; no coding DNA is ever detected in the target capture complex. Separately from its role in V(D)J cle...

Journal: :Annual review of genetics 2011
David G Schatz Patrick C Swanson

V(D)J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development through a series of carefully orchestrated DNA breakage and rejoining events. DNA cleavage requires a series of protein-DNA complexes containing the RAG1 and RAG2 proteins and recombination signals that flank the recombining gene segments. In this review, we discuss recent advances in our unders...

Journal: :Blood 2010
Suk See De Ravin Edward W Cowen Kol A Zarember Narda L Whiting-Theobald Douglas B Kuhns Netanya G Sandler Daniel C Douek Stefania Pittaluga Pietro L Poliani Yu Nee Lee Luigi D Notarangelo Lei Wang Frederick W Alt Elizabeth M Kang Joshua D Milner Julie E Niemela Mary Fontana-Penn Sara H Sinal Harry L Malech

Destructive midline granulomatous disease characterized by necrotizing granulomas of the head and neck is most commonly caused by Wegener granulomatosis, natural killer/T-cell lymphomas, cocaine abuse, or infections. An adolescent patient with myasthenia gravis treated with thymectomy subsequently developed extensive granulomatous destruction of midface structures, palate, nasal septum, airways...

2011
Wayne P. Wahls Mari K. Davidson

Hotspots regulate the position and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicidal and are somehow resurrected elsewhere in the genome. After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key realizations that (A) DNA site-dependent regulation is broadly conserved and (B) i...

Journal: :Proceedings of the National Academy of Sciences 2015

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