Mutation of p53 is the most common genetic alteration observed in human tumours and is reported to lead to variations in cell radiosensitivity. However, the relationship between the mutation point and the degree of radiosensitivity is unclear. Saos-2 cells with different mutations of p53 were prepared and examined for radiosensitivity. Cells with p53 mutations at codons 175, 244, 245, 273 and 2...

Lymphoma is rising in incidence and there is a continued need for new and novel therapeutic options. Lymphomas are extremely radiosensitive, but the majority of patients are not candidates for involved field radiation therapy. An intact immune system has a critical role in suppressing lymphomagenesis. Here we discuss the contribution of various components of the immune system in suppressing the...

Microgliomatosis (Russell, Marshall, and Smith, 1948) or primary reticulosis of the brain (Miller and Ramsden, 1963) is usually considered a pathological curiosity and the diagnosis has almost invariably been made on necropsy material. Yet the structure of the tumour suggests that it may be radiosensitive and every effort should therefore be made to reach a diagnosis during life. In reporting a...

Neoplasms of the skin present fewer technical difficulties in treatment than those more deeply situated. In the average early case of skin cancer, good results are obtainable with a considerable variety of methods. However, should the lesion be extensive, deeply infiltrating, situated over an irregular contour or over radiosensitive or vital structures, one particular method may offer great. ad...

Dividing a dose into a number of fractions spares normal tissues because of repair of SLD between dose fractions and repopulation of cells if the overall time is sufficiently long. At the same time dividing a dose into a number of fractions increases the damage to the tumor because of reoxygenation and reassortment of cells into radiosensitive phases of the cell cycles between dose fractions. T...

Although Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is a highly radiosensitive cancer, approximately 20% of patients with NPC develop local recurrence after radiation therapy. Multiple proinflammatory cytokines are thought to protect NPC tumor cells from immune surveillance and therapeutic interventions. The cytokine leukemia inhibitory factor (LIF) is a critical component of ...

By H. S. WINCHELL, MYRON POLLYCOVE, A. C. ANDERSEN AND J. H. LAWRENCE P RESENTLY available evidence suggests an association between lymphocytic cells and homograft rejection response.13 This possibility led us to develop a procedure for delivering high doses of radiation selective for lymphatic tissue but sparing of other radiosensitive structures. Yttrium-90, chelated by diethylene triamine pe...

UNLABELLED NHL is a highly chemo-sensitive as well as radiosensitive disease. From May 2005 to June 2010, 87 patients were randomised into 2 arms. The control arm received the standard CHOP regimen + IFRT, whereas the study arm received Paclitaxel, 135/m2 additionally. The results showed a better Overall Response (87% vs 78%) in the study arm. The 3yr and 5yr overall survival were significantly...

Hepatocellular carcinoma (HCC) is predominantly diagnosed in advanced stages and not amenable to surgical resection and transplantation. Systemic therapies have had a limited efficacy in treating HCC. Although HCC is a radiosensitive tumor, treatments with external-beam radiation are limited by radiosensitivity of normal liver tissue and surrounding organs-at-risk, i.e. bowel, stomach, and kidn...