نتایج جستجو برای: radioprotective

تعداد نتایج: 1071  

Journal: :Organic & biomolecular chemistry 2013
Marie-Céline Frantz Erin M Skoda Joshua R Sacher Michael W Epperly Julie P Goff Joel S Greenberger Peter Wipf

JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All an...

2014
Mikhail V. Vasin Leonid F. Semenov Nikolai N. Suvorov Vsevolod V. Antipov Igor B. Ushakov Leonid A. Ilyin Boris A. Lapin

The radioprotective effect of indralin in rhesus monkeys was examined over 60 d following gamma irradiation. Male and female rhesus macaques (Macaca mulatta) 2-3-years-old and weighing 2.1-3.5 kg were used. Animals were exposed to total-body gamma irradiation from (60)Co at a dose of 6.8 Gy (lethal dose, 100% lethality over 30 days). Indralin (40-120 mg kg(-1)) was administered intramuscularly ...

Journal: :Journal of radiation research 2004
Harish Chandra Goel Jagadish Prasad Surinder Singh Ravinder Kumar Sagar Paban Kumar Agrawala Madhu Bala Arun Kumar Sinha Ruchi Dogra

A preparation of Tinospora cordifolia (RTc) administered i.p. (200 mg/kg b.w.) to strain "A" male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (CFU), hematological parameters, cell cycle progression, and micronuclei induction. Preirradiation treatment with RTc rendered 76.3% survival (30 ...

Journal: :Bioelectrochemistry 2011
Charles E Turick Amy A Ekechukwu Charles E Milliken Arturo Casadevall Ekaterina Dadachova

The presence of melanin pigments in organisms is implicated in radioprotection and in some cases, enhanced growth in the presence of high levels of ionizing radiation. An understanding of this phenomenon will be useful in the design of radioprotective materials. However, the protective mechanism of microbial melanin in ionizing radiation fields has not yet been elucidated. Here we demonstrate t...

2009
Papiya Bigoniya Avtar Chand Rana

Purpose: Euphorbia neriifolia Linn. (Euphorbiaceae) plant is traditionally used in the treatment of abdominal troubles, bronchitis, tumours, leucoderma, piles, inflammation, and enlargement of spleen. The objective of this study was to evaluate the antioxidant and anticancer activities of a sapogenin isolate of this plant. Methods: Euphol was isolated as a major constituent from the triterpenoi...

Journal: :Brazilian dental journal 2009
Anna Silvia Setti da Rocha Flávia Maria de Moraes Ramos-Perez Frab Norberto Bóscolo Flavio Ricardo Manzi Mariliani Cchicarelo Solange Maria Almeida

This study evaluated the radioprotective effect of sodium selenite on the bone repair process in tibiae of female rats. For such purpose, 100 female Wistar rats (Rattus norvegicus, albinus) were randomly assigned to 4 groups (n=25), according to the treatment received: administration of distilled water (control); administration of sodium selenite; gamma radiation; and administration of sodium s...

2016
Paridhi Gupta Manoshi Gayen Joan T. Smith Elena K. Gaidamakova Vera Y. Matrosova Olga Grichenko Barbara Knollmann-Ritschel Michael J. Daly Juliann G. Kiang Radha K. Maheshwari

The radioprotective capacity of a rationally-designed Mn2+-decapeptide complex (MDP), based on Mn antioxidants in the bacterium Deinococcus radiodurans, was investigated in a mouse model of radiation injury. MDP was previously reported to be extraordinarily radioprotective of proteins in the setting of vaccine development. The peptide-component (DEHGTAVMLK) of MDP applied here was selected from...

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