BACKGROUND The hematopoietic syndrome of the acute radiation syndrome (HSARS) is a life-threatening condition in humans exposed to total body irradiation (TBI); no drugs are approved for treating this condition. Recombinant human interleukin-12 (rHuIL-12) is being developed for HSARS mitigation under the FDA Animal Rule, where efficacy is proven in an appropriate animal model and safety is demo...

Railway rolling noise is radiated by the vibration of the rail and wheel. The TWINS model is well established as a method of predicting the generation of vibration and noise and this has been used successfully to design noise mitigation measures. However, the existing model used to predict the sound radiation from the rail considers the rail to be located in free space whereas, in reality, the ...

A double-null configuration is being considered for the EU-DEMO, due to its potential benefits power exhaust arising from use of two active divertors and magnetically disconnected low- high-field sides. Using systematic parameter scans in fluid simulations, we have investigated divertor EU-DEMO a connected configuration, compared edge plasma properties those obtained single-null under detached ...

PURPOSE pentoxifylline (PTX) and tocopherol (vitamin E) are antioxidants previously shown to be useful in combination in the treatment of late radiation induced toxicity. The purpose of this study was to investigate the benefit of combination therapy with carbogen pentoxifylline and tocopherol in the mitigation of late radiation effects. As the optimal duration of PTX and tocopherol treatment h...