Radiations in medicine cover a wide range of applications, predominantly diagnostic imaging and radiotherapy, encompassing photons (x- γ-rays) particle radiation, as well with the use liquid sources nuclear focusing on physiological functional imaging, tumour detection or targeted radiotherapy. The biological interactions ionizing radiation leads naturally to questions benefits risk following d...

Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-off...

The idea of using hormesis for postponing aging and improving human health has been recently discussed in scientific literature. This paper shows that redundancy in renewal capacity, some portion of which become activated and manifested in hormesis effects, may originate as a result of interaction between living organisms and their environment. It is shown that such redundancy may normally exis...

This article provides a comprehensive review of hormesis, a dose-response concept that is characterized by a low-dose stimulation and a high-dose inhibition. The article traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. The article indicates that the hormetic dose response is the most fundamental dose resp...

Suggesting a need for more research, Mr. Elliott argues that it is too soon for risk-assessment policy to account for recent challenges to a toxicological linear dose-response assumption.

Submission Guidelinesand Abstract Submission

Although radiation carcinogenesis has been shown both experimentally and epidemiologically, the use of ionizing radiation is also one of the major modalities in cancer treatment. Various known cellular and molecular events are involved in carcinogenesis. Apart from the known phenomena, there could be implications for carcinogenesis and cancer prevention due to other biological processes such as...

Single or multiple exposures to mild stress at younger ages often have positive health beneficial effects throughout life, indicating that rescue systems turned on at a young age can be effective even in old age (e.g. Le Bourg 2011). This seems to be at variance with the notion of the so-called trade-offs that due to a limitation of resources it is impossible for an organism to increase all asp...

Hormesis has been defined as a dose-response relationship in which there is a stimulatory response at low doses, but an inhibitory response at high doses, resulting in a U- or inverted U-shaped dose response. To assess the proportion of studies satisfying criteria for evidence of hormesis, a database was created from published toxicological literature using rigorous a priori entry and evaluativ...