Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment strategies. Strategies based on human stem cells offer a promising option. We evaluated efficacy of transplanting a good manufacturing practice (GMP)-grade ...

The algal blooming in the inland lakes has become a critically important issue for its impacts not only on local natural and social environments, but also on global human community. However, the occurrences of blooming on larger spatial scale and longer time scale have rarely been studied. As the third largest freshwater lake in China, Lake Taihu has drawn increasing attention from both public ...

Stopped-flow spectrophotometry was used to study the reduction of cytochrome c by a series of RuII complexes including RuIIL(py-R1-11)x (where L3- is the anion of N-2-hydroxyethylethylenediaminetriacetic acid; py-R is 4-R-substituted pyridine; x = 0, -1, -2) at 298 K under pseudo-first order conditions at pH 7 (phosphate buffer) and I = 0.1 M (NaCl). The variation in R(x) was as follows: R1, H ...

● Baskground and aimr The scarcity and unpredictability of active pollinators during late winter in temperate areas tends to favour extended flowering seasons and increased floral longevity in early blooming species, which are usually pollinated by diverse sets of insects. Daphne laureola is a gynodioecious woody perennial that flowers from January to April in southern Spain, a period character...

BACKGROUND The R6/1 mouse line is one of the most widely employed models of Huntington Disease (HD), a complex syndrome characterized by motor and non-motor deficits. Surprisingly, its behavioral phenotype during the early phases of the pathology when the motor impairments are not manifest yet has been poorly investigated. It is also not clear whether the expression of HD-like symptoms at the p...

research on crop response to deficit irrigation is important to reduce agriculture water use in areas where water is limited resource. using drought resistant landraces with irrigation scheduling based on phenological stages in semi-arid and arid regions may provide an opportunity to optimize irrigation efficiency and water savings in these regions. in order to evaluate of yield and yield compo...

In the present study, various developmental stages of Liza aurata oocyte, especially IV and V stages have been described. On the basis of histological investigations, oocyte development in L. aurata comprises immature (I), the early maturing (II), the late maturing (III), mature (IV), ripe (V), and spent (VI) stages. In the stages I and II, nucleus occupied large volume of oocyte. Vacuolization...