The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative, funded by an R13 from the National Institute of Mental Health, seeks to enhance translational research in treatment development for impaired cognition in schizophrenia by developing tools from cognitive neuroscience into useful measures of treatment effects on behavior and brain function. A...

Vle have developed a predictive corresponding states model for the thermo· physical properties of pure refrigerants and refrigerant mixtures. The bulk phase properties such as the density, enthalpy and entropy are predicted using the prin· ciple of extended corresponding states. This theoretically based model uses shape factors to insure conformality among the various components and R134a is us...

BACKGROUND Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA. Previous studies identified a citrullinated epitope in cartilage proteoglycan (PG) aggrecan that elicited pro-inflammatory cytokine production by RA T cells. We recently reported the presence of ACPA-reactive (citrullinated) PG...

Diolez P, Deschodt-Arsac V, Raffard G, Simon C, Dos Santos P, Thiaudière E, Arsac L, Franconi J-M. Modular regulation analysis of heart contraction: application to in situ demonstration of a direct mitochondrial activation by calcium in beating heart. Am J Physiol Regul Integr Comp Physiol 293: R13–R19, 2007. First published June 1, 2006; doi:10.1152/ajpregu.00189.2006.—Heart contraction is cha...

One-hundred eight Mycobacterium avium isolates from pigs, humans, birds, and bovines were typed by the IS1245-based restriction fragment length polymorphism (RFLP) method and PCR-restriction enzyme analysis (PRA) of hsp65. Nine clusters of isolates showing more than 80% similarity in their RFLP profiles were detected. The largest cluster (cluster B) included 32 of 79 pig isolates (40.5%), 3 of ...

O L I V E R PFA A R1, 2, CL AUS BAC H E R T3, AL B R E C H T BU FE 4, RO L A N D BU H L 5, CH R IS TO F EB N E R 6, PE T E R EN G7, FR A N K FR I E D R I C HS 8, TH O M A S FU C HS 9, EC K A R D HA M E L M A N N10, DO R IS HA R T W I G-BA D E11, TH O M A S HE R I N G12, IS I D O R HU T T E G G E R13, K I R S T E N JU N G14, LU D G E R K L I M E K1, MAT T H I A S VO L K M A R KO PP15, HA NS ME R...

Levosimendan is a calcium sensitizer developed for the treatment of heart failure. It increases contractile force by enhancing the sensitivity of myofilaments to calcium. Besides this sensitizing effect, the drug has also been reported to show some inhibitory action on phosphodiesterase 3 (PDE3). The inotropic effects of levosimendan have been studied on guinea pig paced perfused hearts by usin...

INTRODUCTION High flow (HF) therapy is an increasingly popular mode of non-invasive respiratory support for preterm infants. While there is now evidence to support the use of HF to reduce extubation failure, there have been no appropriately designed and powered studies to assess the use of HF as primary respiratory support soon after birth. Our hypothesis is that HF is non-inferior to the stand...

This paper uses a multi-period economic-environmental Computable General Equilibrium (CGE) modelling framework to analyse local sustainability policy issues. Our focus is the small, open, labourconstrained regional economy of Jersey. The case of Jersey is of particular interest for two main reasons. The first is the unusually low degree of geographical labour market integration for such a small...

As the world’s second largest carbon emitter, China has long been criticised as a ‘free-rider’ enjoying benefits from other countries’ efforts to abate greenhouse gas emissions but not taking due responsibilities of its own. China has been singled out as one of the major targets at the subsequent negotiations after the Kyoto curtain had fallen. By analysing the historical contributions of inter...