Intestinal development is modified by age and nutrition, mediated in part by insulin-like growth factors (IGF-I, IGF-II) and insulin. We have investigated whether expression of IGF-I, IGF-II and insulin receptors (IGF-IR, IGF-IIR and IR; measured by real-time RT-PCR) and binding capacity (Bmax) of IGF-IR, IGF-IIR and IR in the mucosa of the small and large intestine of neonatal calves are modif...

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality. It is associated with airway obstruction, increased airway hyper-responsiveness (AHR), and ongoing airway and lung inflammation dominated by CD8 lymphocytes and neutrophils. Singlenucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have b...

RATIONALE A disintegrin and metalloprotease 33 (ADAM33) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. OBJECTIVES To assess whether SNPs in ADAM33 are associated with accelerated lung function loss in the general population and with chronic ...

Angus and Charolais heifers (195 +/- 7 kg) were actively immunized against growth hormone-releasing factor (GRF) to evaluate the effect on concentrations of somatotropin (ST), insulin-like growth factor I (IGF-I), insulin (INS), growth, and onset of puberty. Primary immunizations were given at 184 +/- 7 d of age (d 0 of experiment) by injecting (s.c.) 1.5 mg of GRF-(1-29)-Gly-Gly-Cys-NH2 conjug...

The purpose of this study was to compare vertical ground reaction forces (GRF) and electromyographic activity (EMG) from peroneus longus (PL), tibialis anterior (TA) and gastrocnemius lateralis (GL) of volleyball athletes with and without functional ankle instability (FI) during landing after a blocking maneuver. Synchronized EMG and GRF from 200ms prior to impact to 200ms after impact were acq...

The aim of this study is to investigate the effect of flooring surfaces in the ground reaction forces and foot/floor friction during stroke gait. The participant was oriented to walk, in its own preferred speed, over two force plates on the following surfaces: HOV, carpet and HTV. The results of this study showed no differences between the hemiparetic and the control group when de GRF and COF w...

Background In-vitro gait simulations have great potential, allowing a systematic analysis of the foot function. However, it is important that the loading conditions are realistic i.e. physiologic ground reaction forces (GRF). In most experiments, in-vivo measured GRF can be imposed [1,2]. However in experimental designs that evaluate the effect of altered muscle forces on foot motion this is mo...