We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance enco...

BMS-284756 (T-3811) is a novel quinolone that lacks a fluorine at the C-6 position. BMS-284756 has a broad spectrum of antibacterial activity (3, 7). The purpose of the present study was (i) to analyze the in vitro activity of the novel quinolone against mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus selected with marketed quinolones and (ii) to investiga...

Recent state-wide surveillance of drug-resistant tuberculosis in the state of Gujarat has shown resistance to flouroquinolones (FQ) in 24 per cent cases (19% among new and 25% among previously treated TB cases)1. This increase of drug resistance correlates well with the very widespread use (the broad indications of this class of antimicrobials in lower-respiratory, gastrointestinal, genitourina...

OBJECTIVE There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. METHODS Isolates from men with urethral discharge presenting at 3 STI clinics in 3 different sites of Armenia were used to determine susceptibility of N. gon...

Sir, BMS-284756 (T-3811) is a novel quinolone that lacks a fluorine at the C-6 position, and is active in vitro against Streptococcus pneumoniae, including strains with elevated ciprofloxacin MICs. Because the various quinolones differ in both target affinity and their activation of efflux pumps, one can speculate that the phenotypic expression of quinolone resistance will also differ. Studies ...

Pseudomonas aeruginosa genus bacteria are well known for their increased drug resistance (phenotypic ang genotypic resistance). The most important resistance mechanisms are: enzyme production, reduction of pore expression, reduction of the external membrane proteins expression, efflux systems, topoisomerase mutations. These mechanisms often accumulate and lead to multidrug ressitance strains em...