The present study is an effort to explore some low molecular weight chemical entities quinazolinone incorporated naphthyl chalcones for their cytotoxic potential and, that can act smartly by inhibiting the mutated targets EGFR (T790M mutation; PDB Id: 5Y9T), and K-RAS(G12D 4EPT). in-vitro studies were done MTT assay method. For lung cancer cell lines (A549), N1-N4 found as more potent than refe...

Quinazolinone derivatives are nowadays well recognized as valuable scaffold in drug discovery. In this manuscript an improved multicomponent process for the chemical synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives is described. Isatoic anhydride and aromatic aldehydes with ammonium acetate have been subjected to a three-component reaction under solvent-free conditions and catalysis of ...