A whole-genome scan was conducted to map quantitative trait loci (QTL) for BSE resistance or susceptibility. Cows from four half-sib families were included and 173 microsatellite markers were used to construct a 2835-cM (Kosambi) linkage map covering 29 autosomes and the pseudoautosomal region of the sex chromosome. Interval mapping by linear regression was applied and extended to a multiple-QT...

Dominance is an important source of variation in complex traits. Here, we have carried out the first thorough investigation of quantitative trait locus (QTL) detection using variance component (VC) models extended to incorporate both additive and dominant QTL effects. Simulation results showed that the empirical distribution of the test statistic when testing for dominant QTL effects did not be...

This paper proposes the use of weighted multiple linear regression to estimate triple3interaction (additive×additive×additive) quantitative trait loci (QTLs) effects. The unweighted yielded an improvement (in absolute value) in QTL×QTL×QTL interaction effects compared assessment based on phenotypes alone three cases (severe drought 2010, control 2012 and severe 2012). In contrast, evaluation aa...

regions on three ovine chromosomes (oar1, oar5 and oar25) were selected to study quantitative trait loci (qtl) segregating for wool traits in baluchi sheep. a total of 503 progeny from 13 half-sib families were genotyped for 15 microsatellite markers. the average number of progeny per sire was 38 and ranged between 16 and 59. data were collected from research centre on baluchi breed in 2009 and...

A novel and robust method for the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is proposed. Linkage information refers to recombinations within the marker-genotyped generations and linkage disequilibrium to historical recombinations before genotyping started. The identity-by-descent (IBD) probabilities at the quantitative t...

Environment-specific quantitative trait loci (QTL) refer to QTL that express differently in different environments, a phenomenon called QTL-by-environment (Q × E) interaction. Q × E interaction is a difficult problem extended from traditional QTL mapping. The mixture model maximum-likelihood method is commonly adopted for interval mapping of QTL, but the method is not optimal in handling QTL in...

Identifying genes responsible for quantitative variation remains a major challenge. We previously identified a quantitative trait locus (QTL) affecting body size that segregated between two inbred strains of mice. By fine mapping, we have refined the location of this QTL to a genomic region containing only four protein-coding genes. One of these genes, PAPPA2, is a strong candidate because it c...