No previous reports are available about the potential dramatic effects resulting from the combination of acquired long QT interval not associated to bradycardia and myocardial ischemia. We report the case of a man that during acute necrotic pancreatitis presented QT interval prolongation without bradycardia, TdP, and two episodes of cardiac arrest. A coronary angiogram revealed a subocclusive s...

We analyzed the QT and RR interval time series continuously recorded during 90 degrees passive Tilt test in 10 young healthy subjects (age 2625 years, 5 females). Changes in QT interval were assessed on 1 minute time related templates and on rate-independent waveforms obtained by averaging beats preceded by the same RR interval. Following Tilt, the mean RR interval shortened from 927273 ms to 7...

Methadone is a synthetic opioid frequently used in drug maintenance programs for heroin addicts. It prolongs the QT-interval and is mainly metabolized by the isoenzyme CYP3A4 of the hepatic cytochrome-P450-system, which is used by numerous other QT-prolonging agents. Its most severe side effect is the development of life-threatening Torsade de pointes ventricular tachycardia in the setting of a...

BACKGROUND Electrocardiographic QT interval prolongation is a risk factor for sudden cardiac death and drug-induced arrhythmia. The clinical correlates and heritability of QT interval duration in blacks have not been well studied despite their higher risk for sudden cardiac death compared with non-Hispanic whites. We sought to investigate potential correlates of the QT interval and estimate its...

1.1 Definition and prevalence Long QT syndrome (LQTS) is a familial condition causing syncope and sudden death through rapid ventricular tachycardia (torsade de pointes), which can deteriorate to ventricular fibrillation, in otherwise fit and healthy young people. Prevalence is approximately 1 in 2,500. 1 Clinical diagnosis is made from a combination of suspicious history, family history and th...

Background: Rate of mortality due to cardiovascular diseases is high in Maintenance Hemodialysis (MHD) patients. Additionally, prolonged QT interval is reportedly associated with high-risk ventricular arrhythmia and sudden death. Vascular calcification may be related to QT dispersion interval in MHD patients because the extensive nature of the calcification process may involve the conducting sy...

Introduction In inherited long QT syndrome (LQTS), female sex is associated with a longer QT interval duration and a higher risk for potentially lethal polymorphic ventricular tachycardia (pVT) and sudden cardiac death than in males. The arrhythmogenic risk is particularly pronounced during the postpartum period—especially in patients with LQTS type 2—but relatively low during pregnancy, indica...

BACKGROUND AND OBJECTIVES Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study investigated whether degarelix at supratherapeutic concentrations has an intrinsic effect per se on cardiac repolarisation and the QT interval. MET...

BACKGROUND Accurate measurement of the QT interval is very important from a clinical and pharmaceutical drug safety screening perspective. Expert manual measurement is both imprecise and imperfectly reproducible, yet it is used as the reference standard to assess the accuracy of current automatic computer algorithms, which thus produce reproducible but incorrect measurements of the QT interval....

Torsade de pointes (TdP) is an uncommon and specific form of polymorphic ventricular tachycardia, associated with a prolonged QT interval. Prolongation of the QT interval is the most widely recognized electrophysiological abnormality in patients with liver cirrhosis. We observed a case of TdP leading to cardiopulmonary resuscitation after the induction of general anesthesia, in a patient with l...