INTRODUCTION AND OBJECTIVES Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming. METHODS In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modi...

OBJECTIVE To report acute and mid-term electrocardiographic changes in patients with hypertrophic obstructive cardiomyopathy (HOCM) after alcohol ablation of the first large septal branch of the left anterior descending coronary artery; and to relate electrocardiographic data with the left ventricular outflow tract pressure gradients. PATIENTS Nine consecutive symptomatic patients with HOCM (...

BACKGROUND Nilotinib is a second-generation tyrosine kinase inhibitor with significant efficacy as first- or second-line treatment in patients with chronic myeloid leukemia. Despite preclinical evidence indicating a risk of prolongation of the QT interval, which was confirmed in clinical trials, detailed information on nilotinib's cardiac safety profile is lacking. DESIGN AND METHODS Here, we...

Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are capable of detecting drug-induced clinical arrhythmia, Torsade de Pointes (TdP), and QT prolongation. Efforts herein employ a broad set of structurally diverse drugs to optimize the predictive algorithm for applications in discovery toxicology and cardiac safety screening. The changes in the beat rhythm and rate of a conf...

We study the homogeneous Dirichlet problem for degenerate parabolic equationut?div(|?u|p(x,t)?2?u)=f(x,t) in QT=?×(0,T), where ??RN, N?2, is a bounded domain with boundary ???C2. The variable exponent p(x,t) given Lipschitz-continuous function, p(x,t):QT?[p?,p+] some constants 2NN+2<p??p+<?. derive conditions on f and u0 sufficient existence of unique strong solution following global regularity...

torsades de pointes is a rare but potentially lethal arrhythmia which mainly occurs in the setting of a prolonged qt interval. ecg is a reliable tool to detect such abnormalities, routinely taken from all patients over 40 who undergo surgery. we describe the case of a 35-year-old woman with torsades de points arrhythmia after hysterectomy surgery. most likely, our patients had long qt syndrome ...

Thirty patients who developed arterial hypertension following coronary artery bypass grafting, despite sedation, were treated randomly with sodium nitroprusside (SNP), ketanserin or urapidil. All drugs significantly decreased arterial pressure. Two patients were withdrawn because hypertension failed to respond to ketanserin. Significant tachycardia was noted only in the SNP group. An increase i...

BACKGROUND Abnormal cardiac repolarization, indicated by a prolongation of the QT interval, increases the risk for torsades de pointes, a potentially life-threatening arrhythmia. Many perioperatively administered drugs and conditions prolong the QT interval. Despite several reports of perioperative torsades de pointes, systematic evidence regarding perioperative QT interval prolongation is limi...