Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent hypereosinophilia (HE) and organ dysfunction that occurs as a result of high levels of tissue eosinophil infiltration and/or extensive deposition of eosinophil-derived proteins. Because it is often difficult to make the differential diagnosis of HES despite conducting a careful evaluation, identifying particular pat...

Resting heart rate (RHR) has been an established predictor for atrial fibrillation (AF). However, the association of visit-to-visit variability (VVHRV) with new-onset AF risk over long term remains unclear. Our study investigates relation VVHRV to in general population prospective Kailuan cohort. A total 46,126 individuals without arrhythmia were included. They underwent 3 health examinations f...

In this article, we examine the social networks of visually impaired and blind adolescents. Data were collected about the size and structure of their network, their subjective evaluation of the network, happiness, loneliness, and a number of individual characteristics. These results are compared with the results of comparable studies on non-handicapped adolescents. Multilevel analysis was used ...

An approximate analytical expression is obtained for the orbits of a charged particle moving in a cusp magnetic field. The particle orbits pass close to or through a region of zero magnetic field before being reflected in regions where the magnetic field is strong. Comparison with numerically evaluated orbits shows that the analytical formula is surprisingly good and captures all the main featu...

Rapid degradation of RNA is the most important factor impeding the analysis of gene expression in human cells and tissues. Once a tissue has been removed from its normal environment, the relative rates of RNA synthesis and degradation change. This in turn gives rise to changes in the relative proportions of various RNA species within a tissue, as well as to an overall reduction of RNA concentra...

Retinoic acid (RA) is involved in hematopoiesis inducing in vitro myeloid differentiation in normal and leukemic progenitor cells.1 In vivo, the complete response to RA is typical of promyelocytic leukemia with PML-RARa rearrangement.2 An erratic and incomplete response to RA as been reported in myelodysplastic syndromes3 and in secondary leukemias combining ATRA with low doses of Ara-C.4 We re...

Loss of a whole chromosome 5 or a deletion of the long arm, del(5q), is a recurring abnormality in malignant myeloid diseases. In previous studies, we delineated a commonly deleted segment of '4 Mb within band 5q31 that was f lanked by IL9 on the proximal side and D5S166 on the distal side. We have generated a physical map of P1 (PAC), bacterial (BAC), and yeast artificial chromosome (YAC) clon...

Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood. Most of the children respond to corticosteroid therapy whereas 10% of them fail to respond to this treatment. They are at risk of extrarenal complications of the nephrotic syndrome and may develop end-stage renal disease, which occurs in up to 50% of white children after a follow-up of 5 yr and 80% of Afri...

A monosomal karyotype (MK) is defined by the presence of two or more autosomal monosomies or one autosomal monosomy and one or more structural abnormality. MK has been shown to have a negative impact on survival in patients with acute myeloid leukemia, primary myelofibrosis and myelodysplastic syndromes. In several studies, the negative prognostic significance of MK in myeloid neoplasms persist...

Occasionally hepatocellular carcinomas (HCCs) occur synchronously with or within focal nodular hyperplasias (FNHs), raising the question of a putative causal relationship. In the present study, we used comparative genomic hybridization to investigate the occurrence of genomic aberrations in FNHs, which might lead to hepatocarcinogenesis. Tissue samples from FNHs and nonlesional liver tissue wer...