Abstract In laser-based powder bed fusion of metals (PBF-LB/M), residual oxygen in the processing atmosphere is regarded as disruptive and disadvantageous for manufacturing process resulting component properties. A novel approach to eliminate add small amounts silane argon gas. Silane eliminates forms SiO 2 nanoparticles, which turn can be incorporated into during process. It therefore necessar...

We have studied, using a telemetry system, the pyrogenic properties of recombinant murine interleukin-18 (rmIL-18) injected into the peritoneum of C57BL/6 mice. The effect of IL-18 was compared with the febrile response induced by human IL-1beta, lipopolysaccharide (LPS), and recombinant murine interferon-gamma (rmIFN-gamma). Both IL-1beta and LPS induced a febrile response within the first hou...

BACKGROUND The gram-positive bacterium Streptococcus pyogenes is a common pathogen of humans that causes invasive infections, toxic-shock syndrome, rheumatic fever, necrotizing fasciitis and other diseases. Detection of antibiotic resistance in clinical isolates has renewed interest in development of new vaccine approaches for control S. pyogenes sepsis. In the study presented, a novel protein ...

Lipid X (2,3-diacylglucosamine-1-phosphate) is a novel monosaccharide precursor of lipid A that has some of the physiologic activities of endotoxin but little toxicity. To determine whether lipid X would interfere with the toxic effects of endotoxin, we pretreated sheep with either 100 or 200 micrograms of lipid X per kg of body weight and then challenged them with a potentially fatal dose of E...

Polycyclic aromatic hydrocarbons (PAHs) are natural, ubiquitous substances in marine environments; they consist of two or more benzene rings fused in various arrangements. A range of biological effects has been demonstrated for these compounds, including acute toxicity, carcinogenicity, mutagenicity, teratogenicity and endocrine disrupting activity (Takeuchi et al., 2009). There are two types o...