An efficient strategy for the synthesis of spiro-pyrrolopyridazines has been developed. When reacted with hydrazine monohydrate, spiro-2H-pyrroles a 1,4-diketone functionality produced novel family heterotricyclic hybrids, spiro-pyrrolopyridazines, specifically spiro{cyclohexane-1,5'-pyrrolo[3,4-d]pyridazine} systems. The condensation reaction monohydrate in refluxing 1-butanol proceeded well a...

The structure of the binuclear title complex, [U(2)(C(5)H(3)N(2)O(2))(4)O(4)(H(2)O)(2)]·2H(2)O, is composed of centrosymmetric dimers in which each UO(2) (2+) ion is coordinated by two ligand mol-ecules. One donates its N,O-bonding group and the other donates both carboxyl-ate O atoms. Each of the latter bridges adjacent uranyl ions. The coordination environment of the metal center is a distort...

The enaminone 2 was reacted with hydrazonyl halides 3a-d to afford the corresponding pyrazole derivatives (6a-d) which reacted with hydrazine hydrate to afford the new pyrazolo[3,4-d]pyridazine derivatives 7a-d, respectively. In addition, compound 2 was reacted with some primary aromatic amines to afford the corresponding secondary enaminones 10a-c and reacted with sulfapyridine or sulfapyrimid...

The synthesis of 6-chloro-3-chloromethyl-1,2,4-triazolo[4,3-b]pyridazine and its vicarious nucleophilic substitution products are described and characterized by spectroscopic methods and X-ray diffraction. The lipophilicities of the title compound, its acetate, and the derived 3-methyl tetrazolopyridazine have been measured and correlated with the chlorine substitution. The title compound co-cr...

The crystal structure of the title compound, [Mg(C(5)H(3)N(2)O(2))(2)(H(2)O)(4)]·2H(2)O, is composed of centrosymmetric monomers in which an Mg(II) ion is coordinated by two carboxyl-ate O atoms from the two pyridazine-4-carboxylate ligands. The monomers linked by O-H⋯O and O-H⋯N hydrogen bonds into layers which are held together by hydrogen bonds in which solvent water O atoms act as donors an...

1,2,5-Chalcogenadiazoles fused with electron-withdrawing heterocycles have been actively investigated for the preparation of organic photovoltaic materials. [1,2,5]Oxadiazolo[3,4-d]pyridazines are much less studied than other chalcogenadiazolopyridazines due to their low availability. In this communication, we report our study showing that 5,6-dihydro-[1,2,5]oxadiazolo[3,4-d]pyridazine-4,7-dion...