نتایج جستجو برای: pyrazolone

تعداد نتایج: 399  

Journal: :Chemistry & biology 2010
Erin M Bowers Gai Yan Chandrani Mukherjee Andrew Orry Ling Wang Marc A Holbert Nicholas T Crump Catherine A Hazzalin Glen Liszczak Hua Yuan Cecilia Larocca S Adrian Saldanha Ruben Abagyan Yan Sun David J Meyers Ronen Marmorstein Louis C Mahadevan Rhoda M Alani Philip A Cole

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-site-directed small molecule inhibitor is not yet known. Here we use a structure-based, in silico screening approach to identify a commercially avai...

Journal: :Carbohydrate polymers 2014
Xiaomei Sun Haohao Wang Xiaofeng Han Shangwei Chen Song Zhu Jun Dai

A fingerprint analysis method has been developed for characterization and discrimination of polysaccharides from different Ganoderma by high performance liquid chromatography (HPLC) coupled with chemometrics means. The polysaccharides were extracted under ultrasonic-assisted condition, and then partly hydrolyzed with trifluoroacetic acid. Monosaccharides and oligosaccharides in the hydrolyzates...

2003

1. Metamizole (synonym: dipyrone) is a pyrazolone non-steroidal anti-inflammatory drug (NSAID). In veterinary medicine it is available as a mono-preparation containing 500 mg/ml metamizolesodium. There are also combination products containing 500 mg/ml metamizole + 4 mg/ml of an antispasmodic agent such as butylscopolaminium bromide. Metamizole preparations are indicated for use in horses, catt...

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