An efficient and facile green synthesis of chalcone derivatives 1a-d was achieved by treatment aromatic aldehydes with 2-acetylthiophene in the presence choline chloride-urea mixture as a deep eutectic solvent. Chalcone 1a used reactive key precursor to design series bio-active heterocycles such pyrimidine, pyrazoline, pyridine, pyridopyrimidine naphthyridine. The Structural formula were confir...

In the title compound, C(18)H(16)N(2)O(3), a potential inhibitor of the cyclo-oxygenase-2 isoenzyme, the pyrazoline ring exists in a flattened envelope conformation with one C atom deviating by 0.463 Å from the mean plane of the remaining four atoms. The puckering of the central oxazine ring is more severe, with one N atom and one C atom displaced by 0.235 (6) and 0.370 (2) Å, respectively, on ...

The parasite Trypanosoma cruzi causes Chagas disease, which remains a serious public health concern and continues to victimize thousands of people, primarily in the poorest regions of Latin America. In the search for new therapeutic drugs against T. cruzi, here we have evaluated both the in vitro and the in vivo activity of 5-hydroxy-3-methyl-5-phenyl-pyrazoline-1-(S-benzyl dithiocarbazate) (H2...