Pyrazole is a five membered heterocyclic ring which is a versatile leading compound for designing potent bioactive agents. This interesting group of compounds has diverse biological activities such as antimicrobial, anti-inflammatory, analgesic, anticonvulsant, anticancer, anthelmintic, antioxidant and herbicidal. Results of numerous derivatives of different pyrazole and their substitutions are...

In the title compound, C(19)H(14)Cl(2)F(3)N(5)O(2), which shows insecticidal activity, the dihedral angle between the pyrazole and pyridine rings is 68.15 (16)°. In the crystal structure, the mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds and an intra-molecular N-H⋯O inter-action also occurs. The F atoms of the -CF(3) group are disordered over two sets of sites in a 0.800 (8):0.200 (8)...

a new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...

This work describes the rich self-assembly behavior obtained by grafting a pyrazole-derived platform at focal point of poly(benzyl ether) dendrons. Liquid crystals and supergels made out fibers are supramolecular organization non-discoid entities, they notably increment photoluminescence in these aggregated states (Aggregation-Induced Emission, AIE). The novel point, which is derived from 3,5-d...

Pyrazole ring containing heterocyclic molecules have been known to show biological activity. In this work, by realizing the cyclization reactions of diketonic Michael adducts, synthesis new pyrazole compounds was accomplished. Diketonic adducts were prepared in low-good yields addition acetylacetone nitrovinyl arene presence piperidine. obtained high via these molecules. Structures all and prod...

The correlation between the in vivo toxicity and in vitro mutagenicity of dimethylnitrosamine and the activity of dimethylnitrosamine demethylase I (DMND I) after pyrazole treatment of rats was studied. The biological effects of pyrazole were measured either as toxicity to the rats or as mutations to Salmonella TA 92. A dose-response relationship was observed between DMND I activity and the adm...

Argininosuccinate synthase (ASS) is the rate-limiting enzyme in the urea cycle. Along with nitric oxide synthase (NOS)-2, ASS endows cells with the L-citrulline/nitric oxide (NO·) salvage pathway to continually supply L-arginine from L-citrulline for sustained NO· generation. Because of the relevant role of NOS in liver injury, we hypothesized that downregulation of ASS could decrease the avail...

This paper studies the corrosion inhibition of Al-Mg alloy system in 0.5 mol/dm3 NaCl solution in the presence of pyrazole derivative using potentiodynamic polarization and linear polarization method. The inhibition efficiency as a function of concentration and temperature was investigated. From the polarization curves, it can be concluded that the pyrazole derivative be...

A series of aluminium complexes containing anilido-pyrazolate ligands is described. Reactions of four anilido-pyrazolate ligand precursors, HNPhPz, HNPhTriMePz, HNPhOMePz, or HNPhSMePz [HNPhPz = ortho-C6H4(NH-phenyl)(1-pyrazole); HNPhTriMePz = ortho-C6H4(NH-2,4,6-trimethylphenyl)(1-pyrazole); HNPhOMePz = ortho-C6H4(NH-2-methoxyphenyl)(1-pyrazole); HNPhSMePz = ortho-C6H4(NH-2-methylthiophenyl)(1...