THE INTRINSIC AND SYNAPTIC PROPERTIES OF INVERTED PYRAMIDAL CELLS WITHIN THE NEOCORTEX

Perisomatic inhibition from basket cells plays an important role in regulating pyramidal cell output. Two major subclasses of CA1 basket cells can be identified based on their expression of either cholecystokinin (CCK) or parvalbumin. This study examined their fates in the mouse pilocarpine model of temporal lobe epilepsy. Overall, immunohistochemical labeling of GABAergic boutons in the pyrami...

The hypothesis that recurrent inhibition in the hippocampus is mediated by interneurons was tested with simultaneous intracellular recordings from the CA1 region of guinea pig hippocampal slices in vitro. In recordings from 101 pairs of pyramidal cells, no interactions were detected in 87% of the pairs. In 13% of the pyramidal cell pairs, spike trains induced in one cell caused inhibitor postsy...

Cortical fast-spiking (FS) interneurons are electrically interconnected through gap junctions and form dendritic net structures extending over different functional columns. Here we investigated how pyramidal cells regulate FS cell network activity. Using paired recordings and glutamate puff stimulations, we found that FS cell pairs connected by electrical synapses shared common inputs from surr...

Patch-clamp recordings of CA1 interneurons and pyramidal cells were performed in hippocampal slices from kainate- or pilocarpine-treated rat models of temporal lobe epilepsy. We report that gamma-aminobutyric acid (GABA)ergic inhibition in pyramidal neurons is still functional in temporal lobe epilepsy because: (i) the frequency of spontaneous GABAergic currents is similar to that of control an...

In the present study, we investigated how directional tuning of putative pyramidal cells is sharpened by inhibition from neighboring interneurons. First, different functional and electrophysiological criteria were used to identify putative pyramidal and interneuronal subtypes in a large database of motor cortical cells recorded during performance of the three-dimensional center-out task. Then w...

Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have characterized the firing properties of cells in the hippocampal network includi...