Nocardia is a ubiquitous microorganism related to pyogranulomatous infection, which is difficult to treat in humans and animals. The occurrence of the disease is on the rise in many countries due to an increase in immunosuppressive diseases and treatments. This report of cases from Brazil presents the genotypic characterization and the antimicrobial susceptibility pattern using the disk-diffusi...

Virulent Rhodococcus equi causes pyogranulomatous bronchopneumonia in foals. The route of infection of foals has been considered to be inhalation of aerosolized bacteria from soil that is contaminated with equine feces. Thus, disease caused by R. equi has been regarded as an opportunistic infection of environmental origin and not a contagious disease. In this study, we report the exhalation of ...

Rhodococcus equi is one of the most important causes of disease in foals. Infection is typically characterized by pyogranulomatous pneumonia although extrapulmonary infections occur occasionally. Uveitis and polysynovitis have been reported in foals naturally infected with R. equi and are thought to be the result of an immune-mediated process. However, the pathogenesis of these conditions is po...

Duration of efficacy and prevalence of side-effects associated with GonaCon Immunocontraceptive Vaccine (GonaCon) in free-ranging female elk (Cervus elaphus) are unknown. In January 2008, we captured 120mature female elk in RockyMountain National Park (CO, USA), determined pregnancy status, and randomly assigned them to treated (n1⁄4 60; 1.5mL of GonaCon) or control (n1⁄4 60; 1.5mL of saline) g...

Rhodococcus equi (R. equi) is an intracellular macrophage-tropic pathogen with potential for causing fatal pyogranulomatous pneumonia in foals between 1 and 6 months of age. In this study, we sought to determine whether infection of macrophages with R. equi could lead to the induction of autophagy. Murine bone marrow derived macrophages (BMDM) were infected with R. equi for various time interva...

Background & Aims: It is more than half of a century that the drug of choice for treatment of cutaneous leishmaniosis (CL) has been pentavalent antimony compounds such as meglumine antimoniate (Glucantime). The aim of the present study was to evaluate the efficacy, relapse and treatment failure of intralesional Glucantime plus cryotherapy in the treatment of anthroponotic CL (ACL). Methods: The...

CASE SUMMARY A 2-year-old female spayed domestic shorthair cat was presented for a progressive subcutaneous nasofacial swelling. Histology of biopsy tissue revealed pyogranulomatous inflammation and large numbers of gram-negative capsulated bacterial coccobacilli within macrophages. The isolate was fastidious and grew after 6 days under microaerophilic conditions in a candle jar. The molecular ...

conclusions small size, smooth lesion border and homogeneity favor benign nature of the incidental splenic lesions, while restricted diffusion might be a feature of malignancy. follow-up imaging might be helpful in a subset of patients to discriminate benign and malignant incidental splenic lesions. methods this retrospective study was performed in a tertiary referral center. data of patients w...