The purpose of this study was to obtain an amorphous system with minimum unit operations that will prevent recrystallization of amorphous drugs since preparation, during processing (compression) and further storage. Amorphous celecoxib, solid dispersion (SD) of celecoxib with polyvinyl pyrrollidone (PVP) and co-precipitate with PVP and carrageenan (CAR) in different ratios were prepared by the ...

OBJECTIVE Posteroventral pallidotomy (PVP) has proved to be an effective method for the treatment of Parkinson's disease. However, data on bilateral procedures are still limited. To assess the effects of bilateral globus pallidus (GPi) lesion and to compare it with a combination of unilateral GPi lesion plus contralateral GPi stimulation (PVP+PVS), an open blind randomised trial was designed. ...

We investigated the electrical and mechanical stability of flexible 6,13-bis (triisopropylsilylehtynyl)pentacene (TIPS-pentacene) thin-film transistors (TFTs) that were fabricated on polyimide (PI) substrates using cross-linked poly(4-vinylphenol) (c-PVP) and c-PVP/yttrium oxide (Y2O3) nanocomposite films as gate insulators. Compared with the electrical characteristics of TIPS-pentacene TFTs wi...

Modified release formulations offer several advantages over conventional systems used in therapeutics. The aim of this work was to extend our previous studies on the chronobiotic hormone melatonin controlled release, by comparing its release from uncoated, compression-coated and bilayer tablets. Each tablet was comprised of melatonin and combinations of the following excipients: ethylcellulose,...

Here we report a product evaluation for a non-adherent, povidone-iodine (PVP-I) dressing, determining the clinical need for the product, performing a literature review, clinical evaluation and cost-analysis, and developing a recommendation. This evaluation included 20 patients who experienced dressing pain with the previous antimicrobial dressing. Two patients discontinued the evaluation and fo...

Photoselective vaporisation of the prostate (PVP) is an established treatment option for bladder outlet obstruction (BOO). PVP has demonstrated durable clinical efficacy equivalent to other endoscopic procedures at 5 years [1]. Furthermore, PVP has demonstrated superior haemostatic properties compared with other endoscopic treatments for Benign Prostatic Hyperplasia (BPH) [2]. Despite this many...

One of the most important consequences of acute left ventricular dysfunction (LVD) is pulmonary edema resulting from a rise in pulmonary venous pressure (PVP). It is generally believed that the PVP rise is a direct hemodynamic consequence of LVD. While this paradigm seems plausible, especially if the LV is viewed as a sump pump, there is no specific evidence to support this simple explanation. ...

PURPOSE To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing monopolar transurethral resection of the prostate (MTURP) and photoselective vaporization of the prostate (PVP) in order to provide the most up-to-date and reliable recommendations possible. MATERIALS AND METHODS Relevant RCTs were identified from electronic databases for meta-analysis of...

clarithromycin (cla), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. the aim of this investigation was to prepare cla nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (sls) and polyvinyl pyrrolidone (pvp) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. different weight rati...

silver nanowires were synthesized by solvothermal method through reducing silver nitrate (agno3) with ethylene glycol (eg) in the presence of polyvinylpyrrolidone (pvp). in order to prevent the agglomeration of ag+ in the initial ag seeds formation, sodium chloride (nacl) was added into the solution to form agcl colloids. by dissolving agcl in the late stages, ag+ ions were released into the so...