Schizophrenia (SZ) is a biochemically complex disorder characterized by widespread defects in multiple metabolic pathways whose dynamic interactions, until recently, have been difficult to examine. Rather, evidence for these alterations has been collected piecemeal, limiting the potential to inform our understanding of the interactions amongst relevant biochemical pathways. We herein review per...

Recent studies have shown that pyrroline 5-carboxylate, the intermediate in the interconversions of proline, ornithine, and glutamate, can regulate the metabolism of erythrocytes. We now report that the formation of 5-phosphoribosyl 1-pyrophosphate (PP-Rib-P) was markedly stimulated by pyrroline 5-carboxylate in intact red cells. The production of PP-Rib-P is an important point of regulation in...

BACKGROUND Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism. Further, IMP and GMP represent industrially relevant biotechnological products used as flavor enhancing additives in food industry. Therefore, this work aimed towards the accumulation of IMP a...

There is considerable evidence that a critical reaction in purine synthesis is the closure of the purine ring by the addition of a “formate” group to 4-amino-5-imidazolecarboxamide ribonucleotide (1). Apparently the “formate” is added as an active intermediate, since formate as such has little effect in stimulating purine synthesis. Indeed, there is a demonstrable difference in the utilization ...

Methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and methionine metabolism, is present in all normal tissues but is frequently deficient in a variety of cancers. It has been suggested that this metabolic difference between normal and cancer cells may be exploited to selectively treat MTAP-negative cancers by inhibiting de novo purine synthesis and by depleting L-methionine...

Crop productivity depends on nitrogen fertilization, but plants take up only an average of 30–50% the applied nitrogen. Developing rice cultivars with improved use efficiency or low-nitrogen (LN) tolerance is critical for sustainable agriculture. In this study, a backcross introgression line (G9) 15 introgressed regions from donor parent and its recurrent Shuhui 527 (G1), which are differential...

Gout is classed among the inborn errors of metabolism,1 but unlike the majority of such disorders no single specific metabolic defect has yet been found to account for the hyperuricemia characteristic of this disease.2 Although impaired renal excretion of uric acid is responsible for the hyperuricemia of some patients, an increased rate of purine biosynthesis de novo contributes to the hyperuri...

Recently Benedict1 reported the’ observation that the Dalmatian breed of coach hound exhibits a marked peculiarity in its purine metabolism, to t,he extent that it excretes large amounts of uric acid, even when on a purine-free diet. This peculiarity was exhibited by four Dalmatians examined, but a fifth, “obviously not of very pure breed,” did not eliminate much uric acid. That a single specie...