The capacity of several purinethiol derivatives to produce prolongation of survival in mice bearing ascites-cell tumors and to produce feedback inhibition of purine synthesis in vivo in the tumor cells was investigated. Included were tumors susceptible and tumors resistant to treatment with 6-thioguanine. With susceptible tumors, certain of the purinethiols could increase survival of tumor-bear...

Using a paraffin impregnated graphite electrode (PIGE) and mercury-modifiedpyrolytic graphite electrode with basal orientation (Hg-PGEb) copper(II) and Cu(II)-DNApurine base solutions have been studied by cyclic (CV) and linear sweep voltammetry(LSV) in connection with elimination voltammetry with linear scan (EVLS). In chlorideand bromide solutions (pH 6), the redox process of Cu(II) proceeded...

The use of matrix-assisted laser desorption mass spectrometry (MALDI-MS) has been suggested as an ultrafast readout of Sanger DNA sequencing ladders in a manner analogous to that used with sequencing gels. Currently, a serious limitation of MALDI-MS for the analysis of DNA results from the tendency for oligonucleotides to undergo facile fragmentation in the gas phase. The present study was unde...