RATIONALE The extent to which sarcoplasmic reticulum Ca(2+)ATPase (SERCA) activity alone determines left ventricular (LV) pump function is unknown. OBJECTIVE To correlate SERCA activity with hemodynamic function of rabbit LV during thapsigargin perfusion. METHODS AND RESULTS Isolated rabbit hearts were perfused in working heart configuration, and LV pump function was assessed using a pressu...

With HeartMate II (HMII) implants increasing so has the frequency of device exchange. However, identifying inflow cannula obstruction, pump thrombosis, or outflow obstruction as the mechanism of pump dysfunction can be difficult. Echocardiography, CT angiogram, and cardiac catheterization are not definitive in determining the location of pump failure. Therefore, intraoperative examination is of...

Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constitutive transsarcolemmal Na flux with the Na channel opener veratridine in whole-cell patch-clamp recordings. Using 25 mM Na in the patch pipette, pump currents d...

The security and stability of the pump system have received extensive attention in hydraulic engineering, especially in nuclear system. Transient operations, such as the rapid closure of a valve, a sudden switch over and start procedure of pumps and pump failure will cause sudden flow variation in the pipe system. This phenomenon, known as water hammer, will cause transient effects on the pump....

OBJECTIVES To see the early post-operative outcomes of off-pump versus on-pump coronary artery bypass graft surgery. METHODS This retrospective analytical study was conducted at Ch. Pervaiz Elahi Institute of Cardiology Multan, Pakistan. Our Primary outcome variables were; necessity of inotropic support, nonfatal myocardial infarction, ICU stay, nonfatal stroke, new renal failure requiring di...

We reviewed clinical evidence for the use of ivabradine in systolic heart failure (HF), in which it appears to improve symptoms, improve quality of life, prevent hospitalization, and prolong survival, thereby addressing unmet needs in the management of HF. Ivabradine provides symptomatic benefits in HF on top of standard therapies, in terms of functional parameters and exercise capacity, and th...

Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body. Congestive heart failure is characterized by ...

This study aimed to evaluate on-pump versus off-pump coronary artery bypass grafting (CABG) in patients with a high-risk operative profile.The pre-, intra- and post-operative data of high-risk patients with additive European system for cardiac operative risk evaluation (additive Euro-SCORE) over 6 undergoing isolated CABG from January 2008 to December 2011 in this center were investigated and r...