BACKGROUND Several treatment options are available for pulmonary vascular disease, and more patients are considered for right heart catheterization. The aims of this study were to evaluate the diagnostic ability of echocardiography to detect pulmonary hypertension and increased pulmonary vascular resistance (PVR). METHODS This retrospective study comprised 118 patients investigated within 48 ...

INTRODUCTION The occurrence of pulmonary artery dissection is extremely rare in patients without pulmonary hypertension, congenital cardiac abnormalities or cardiac intervention. A diagnosis of pulmonary artery dissection is rarely made during life because it generally leads to cardiogenic shock and sudden death. The progression or natural course of pulmonary artery dissection is not known and ...

Adolescent, 13 yrs, with slight fatigue and cyanosis since birth. No heart failure, oxygen saturation > 80% and continuous murmur +/++ at the inferior left sternal border. Chest x-ray showed higher caliber vessels to the left. Left pulmonary artery hypertension (90/45-60 mm Hg and 7.8 UW) and normotension to the right (20 mm Hg, 1.8 UW). Left pulmonary artery originated from the ascending aorta...

Pulmonary hypertension is a complication of sarcoidosis leading to dyspnea and associated with increased morbidity and mortality. Sarcoidosis-associated pulmonary hypertension (SAPH) can be due to several factors, including vascular involvement by the granulomatous inflammation, compression of the pulmonary arteries by adenopathy, fibrotic changes within the lung, and left ventricular diastolic...

BACKGROUND AND OBJECTIVES Endothelin-1 has been associated with development of hypoxia-related pulmonary hypertension and vascular endothelial growth factor (VEGF) with protection from this complication. In Chuvash polycythemia, homozygous germline von Hippel-Lindau (VHL) 598C->T leads to up-regulation during normoxia of hypoxia inducible factor-1a and several hypoxia-controlled genes including...

1 Pulmonary Circulation Pulmonary Circulation: A new venue for communicating your fi ndings, ideas and perspectives Welcome Pulmonary circulation is the flow of blood from the right ventricle through the pulmonary artery to the lungs, where carbon dioxide (CO 2) is exchanged for oxygen (O 2), and back through the pulmonary vein to the left atrium. The pulmonary vasculature includes the arteries...

BACKGROUND Pulmonary hypertension is caused by a heterogenous group of disorders with diverse pathophysiological mechanisms, with ultimate structural changes in the pulmonary vascular bed. Platelet activation plays an important role in the development of pulmonary arterial hypertension, while it is unknown whether it contributes to pathogenesis in other conditions. We aimed to investigate plate...