Background There is still a need of further biomarkers for an early and correct diagnosis of PAH as mean time between onset of symptoms and diagnosis is two years. We investigated markers for pressure overload and markers for remodeling in two animal models of PAH, in order to differentiate between biomarker regulation due to afterload increase based on remodeling of pulmonary vessels (monocrot...

The objectives of this study were to assess the feasibility of low flow right ventricular support and to describe the hemodynamic effects of low versus high flow support in an animal model of acute right ventricular pressure overload. A Synergy Pocket Micro-pump (HeartWare International, Framingham, MA) was implanted in seven sheep. Blood was withdrawn from the right atrium to the pulmonary art...

In a canine puppy model, pulmonary artery stenosis was created by banding the left pulmonary artery to 30-40% of its original diameter. Animals underwent right heart catheterization and angiography 1-2 mo later, and Palmaz P308 stents were implanted. Stent redilation was performed 3-5 mo later. One mo postredilation, the animals were restudied and sacrificed. Coarctations of the aorta were crea...

THE MANAGEMENT of complete transposition of the great arteries remains one of the most challenging problems in the operative treatment of congenital heart disease. Although a completely corrective operation is feasible,1 2 in most centers the mortality associated with this procedure is prohibitive, and it is likely to remain high among the seriously ill infants who form the vast majority of pat...

THE MANAGEMENT of complete transposition of the great arteries remains one of the most challenging problems in the operative treatment of congenital heart disease. Although a completely corrective operation is feasible,1 2 in most centers the mortality associated with this procedure is prohibitive, and it is likely to remain high among the seriously ill infants who form the vast majority of pat...

THE MANAGEMENT of complete transposition of the great arteries remains one of the most challenging problems in the operative treatment of congenital heart disease. Although a completely corrective operation is feasible,1 2 in most centers the mortality associated with this procedure is prohibitive, and it is likely to remain high among the seriously ill infants who form the vast majority of pat...