BACKGROUND/AIMS Pterygia are a common disorder of the ocular surface. The disease represents a chronic fibrovascular and degenerative process thought to originate at the conjunctival-corneal junction, where altered limbal stem cells are proposed to be the cell of origin. Extensive epidemiological evidence exists to implicate ultraviolet B irradiation in the pathogenesis of pterygia. To date no ...

OBJECTIVE To compare the excision of primary pterygium by bare sclera technique and excision combined with amniotic membrane transplantation (AMT). STUDY DESIGN An experimental study. PLACE AND DURATION OF STUDY Eye Department, Military Hospital, Rawalpindi, presently known as Armed Forces Institute of Ophthalmology, Rawalpindi, from May 2007 to July 2008. METHODOLOGY A pilot study of 70 ...

BACKGROUND The exact pathogenesis of pterygium is still not fully understood. Growth factors are considered to play an important role in the formation of pterygium. Transforming growth factor (TGF)-β1 is considered to be one of the main mediators of fibroblast stimulation and tissue remodeling in allergic conditions. The objective of the present study was to investigate the association between ...

Background/aim: This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva. Materials and methods: The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with hea...

INTRODUCTION There are numerous adjunctive measures described to reduce the recurrence rates after pterygium excision. OBJECTIVE To study the efficacy and complications of sutureless and glue free limbal conjunctival autograft for the management of primary pterygium over a period of one year. MATERIALS AND METHODS A prospective interventional case series was carried out in 40 consecutive ey...

purpose: to report the result of limbal autografting in primary and recurrent pterygium. methods: in this case series, all patients who were referred to our clinic at farabi hospital, isfahan, iran for treatment of pterygium were included. indications of surgery included chronic ocular irritation, impaired or threatened vision, ocular motility problem and cosmetic reasons. under subconjunctiona...

Biological effects of nerve growth factor (NGF) are mediated through receptors known as nerve growth factor receptors (NGFR), which include p75 and TrkA. This study was initiated after identifying NGFR as an up-regulated gene in the limbus by cDNA microarray analysis and we postulate that its expression may be indicative of a stem/progenitor cell phenotype. Immunohistochemistry was performed on...

Objective: The objective of this selective EBM review is to determine whether or not Bevacizumab is an effective treatment in inhibiting the growth of recurrent pterygium. Study Design: Review of three published, English language randomized controlled trials published in 2010, 2012, and 2013. Data sources: Three randomized controlled trials measuring the efficacy of Bevacizumab to inhibit the g...

Background: Assessing the effect of limbal autograft shifting in recurrence of pterygium. Methods: This single-center study was carried out in a tertiary health facility. A review of data on consecutive patients who underwent pure limbal autografts shifting after pterygium resection was done. In all the cases, the pterygia extended at least 3 mm beyond the limbus. The resected each limbal graft...