the aim of this study was to investigate the effects of ethanolic extract of the whole plant of phyllanthus rheedii wight p.rheedii as antihyperglycemic, antihyperlipidemic and antioxidant effect in streptozotocin (stz) induced diabetic rats. male wistar rats were administered p.rheedii (250 mg/kg) orally for 21 days and blood glucose level was measured weekly. at the end of 21 days, the serum ...

Background : Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte ChemoattractantProte...

background: the b-cell defect in x-linked agammaglobulinemia (xla) is caused by mutations in the gene for bruton's tyrosine kinase (btk). btk mutations result in deficient expression of btk protein in peripheral blood monocytes. methods: using the anti-btk monoclonal antibody (48-2h), a flow cytometric analysis of intra cytoplasmic btk protein expression in monocytes was performed to ident...

The analysis of protein domains has gained considerable attention over the last years. Many new insights on protein modular evolution, combined with improved domain detection, have paved the way for an integrated analysis of protein families from a domain-centric perspective. We recently released DoMosaics, a JAVA application that facilitates the interactive analysis of protein domain arrangeme...

Fusion of two genes at DNA level produces a single protein, known as a chimeric protein. Immunotoxins are chimeric proteins composed of specific cell targeting and cell killing moieties. Bacterial or plant toxins are commonly used as the killing moieties of the chimeric immunotoxins. In this investigation, the catalytic domain of Shiga-like toxin (A1) was fused to human granulocyte macrophage ...

BACKGROUND While many authors have discussed models and tools for studying protein evolution at the sequence level, molecular function is usually mediated by complex, higher order features such as independently folding domains and linear motifs that are based on or embedded in a particular arrangment of features such as secondary structure elements, transmembrane domains and regions with intrin...

background: polycystic ovary syndrome (pcos) is a common disorder of infertility which affects more than 100 million women. it is characterized by chronic anovulation, hyper androgenism and obesity. pcos is also associated with oxidative stress changes. objective: here, we aimed to investigate the level of antioxidants and oxidative stress in iranian women with pcos as a predictive factor for c...