نتایج جستجو برای: protein family
تعداد نتایج: 1570166 فیلتر نتایج به سال:
Brain function requires neuronal activity-dependent energy consumption. Neuronal energy supply is controlled by molecular mechanisms that regulate mitochondrial dynamics, including Kinesin motors and Mitofusins, Miro1-2 and Trak2 proteins. Here we show a new protein family that localizes to the mitochondria and controls mitochondrial dynamics. This family of proteins is encoded by an array of a...
The PROSITE database consists of biologically significant patterns and profiles formulated in such a way that with appropriate computational tools it can help to determine to which known family of proteins (if any) a new sequence belongs or which known domain(s) it contains.
Mapping the Structural Landscape of Protein Families with Geometric Feature Vectors
MOTIVATION The characterization of the folding degree of chains is central to the elucidation of structure--function relationships in proteins. Here we present a new index for characterizing the folding degree of a (protein) chain. This index shows a range of features that are desirable for the study of the relation between structure and function in proteins. RESULTS A novel index characteriz...
Protein structure is generally more conserved than sequence, but for regions that can adopt different structures in different environments, does this hold true? Understanding how structurally disordered regions evolve altered secondary structure element propensities as well as conformational flexibility among paralogs are fundamental questions for our understanding of protein structural evoluti...
Classification of a newly discovered protein into a family of proteins enables the determination of its function. The eMOTIF system identifies conserved modular domains that confer functionality or structure to proteins and allows classification of proteins into families based on the conserved domains a protein contains. A program called multeeMOTIF has been developed which analyzes eMOTIFS and...
The Flower protein family is part of a cell-cell communication pathway that regulates cell competition, in which fit cells eliminate less fit neighbors. A new study demonstrates that this pathway can also govern the culling of unwanted neurons during development.
Direct or indirect inter-residue interactions in proteins are often reflected by mutations at one site that compensate for mutations at another site. Various bioinformatic methods have been developed for detecting such correlated mutations in order to obtain information about intra- and inter-protein interactions. Here, we show by carrying out a correlated mutation analysis for non-interacting ...
Origami is the Japanese art of folding a piece of paper into complex shapes and forms. Much like origami of paper, Nature has used conserved protein folds to engineer proteins for a particular task. An example of a protein family, which has been used by Nature numerous times, is the thioredoxin superfamily. Proteins in the thioredoxin superfamily are all structured with a beta-sheet core surrou...
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