Introduction. Catabolic syndrome is typical for most critical illness situations. A long progressive course of hypercatabolism considered by a number authors as prognostic criterion negative clinical outcome the disease. Objective. Evaluation value some indicators severity catabolic in ICU patients with COVID-19. Materials and methods. prospective cohort study was conducted 55 intensive care un...

To discuss amino acids as energy sources seems at first sight a rather bizarre notion. It is not that there are any particular difficulties in accepting the concept, but rather that it seems a somewhat extravagant or whimsical idea, rather like a discussion of caviar as a pig food. Nevertheless, the topic does merit discussion. For some animals protein regularly predominates in the diet. In adu...

The turnover and tissular uptake of HDL (d 1.095-1.21) have been compared in normocholesterolemic or genetically hypercholesterolemic rats by a constant infusion method of [14C] sucrose labelled HDL for 8 h. The HDL clearance rate was not significantly smaller in the RICO than in the normocholesterolemic animal (320 +/- 22 microliters.h-1 versus 366 +/- 24 microliters.h-1 per 100 g of rat). It ...

Mechanical stretch can activate muscle and myotube protein synthesis through mammalian target of rapamycin complex 1 (mTORC1) signaling. While it has been established that tumor-derived cachectic factors can induce myotube wasting, the effect of this catabolic environment on myotube mechanical signaling has not been determined. We investigated whether media containing cachectic factors derived ...

Maximisation of growth rate is an important fitness strategy for bacteria. Bacteria can achieve this by expressing proteins at optimal concentrations. This is exemplified in Escherichia coli by the covariation of its ribosome protein-fraction with growth rate. It increases with growth rate and precisely matches the increased protein synthesis demand. These findings and others have led to the hy...

based on the randic suggestion of the resolution of a structure into shape, size, and function an index representing structure-catabolic fate relationships of amino acids is constructed. the index obtained by multiplying three factors; (nb2 + nr), nc and m; representing shape, size and function respectively, where nb2 = number of double bonds, nr = number of rings, nc = number of carbon atoms, ...

Formost of this century agriculture and industry haveused a wide range of synthetic chemicals which appear to have no counterparts in nature. Many of these compounds, by their very nature and complexity, are resistant to degradation when released into soil, water and air. Unfortunately, the repeated use and release of such synthetics has become an everyday occurrence, resulting in widespread en...

Frugivorous and nectarivorous bats fuel their metabolism mostly by using carbohydrates and allocate the restricted amounts of ingested proteins mainly for anabolic protein syntheses rather than for catabolic energy production. Thus, it is possible that genes involved in protein (amino acid) catabolism may have undergone relaxed evolution in these fruit- and nectar-eating bats. The tyrosine amin...

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis. These conditions activate the family of Forkhead Box (Fox) O transcription factors. Here we report that muscle-specific deletion of FoxO members protects from muscle l...

Introduction One of the most pronounced metabolic changes after injury, sepsis and other critical illness is increased urinary excretion of nitrogen, resulting in negative nitrogen balance. There is evidence that skeletal muscle is the major source of nitrogen in these conditions. Muscle catabolism during sepsis is mainly caused by increased protein degradation, in particular myofibrillar prote...