Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...

Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI...

BACKGROUND Puerarin has protective effects on ischemia-reperfusion injury, but the underlying mechanisms are not fully revealed. This study explored the effect of puerarin on the expression of Bcl-2 associated athanogene 3 (BAG3) in an in vitro model of anoxia/reoxygenation injury (A/RI) in neonate rat primary cardiomyocytes and the functions of BAG3 in A/RI. MATERIAL/METHODS BAG3 expression ...

Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...

in the present study, protective effect of teucrium polium l. (labiatae) extract on acetaminophen-induced hepatotoxicity was investigated in mice. animals were divided into six groups, each group consist of 8 mice. group one as the negative control group received normal saline, while group two received only crude extract of t. polium l. (500 mg/kg) for five days and group three as the positive ...

objective: the purpose of this study was to identify affecting factors on students’ environmental protection behavior (sipb). methods: statistical population of this research consisted of 1480 students in alborz agricultural technical higher education centers. a stratified random sampling method was used to select 145 student applying cochran's formula. the main tool to collect data was a resea...