Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking. In the course of modeling malignant melanoma in a tyrosinase promoter transgenic system, we developed a genetically-engineered mouse (GEM) model of invasi...

Since the discovery of alpha-methylacyl CoA racemase (AMACR) in prostate cancer in 2000, there have been a number of publications studying the diagnostic value of this enzyme. Although the role of this enzyme is still unknown, the application of AMACR immunohistochemistry in pathology practice has been increased sharply in the last few years. We are going to review the recent studies of the AMA...

OBJECTIVE Prostate cancer (PC) is one of the most common cancer and an important reason of cancer specific death. The incidence of patients who diagnosed at low stage increased because of widespread using Prostate Specific Antigen (PSA) testing. We evaluated the patients who were diagnosed single microscopic focus of adenocarcinoma and treated radical prostatectomy at final pathology. METHODS...

We present the magnetic resonance spectroscopy imaging (MRSI) analysis functionality of DIROlab, an integrated software platform for cancer diagnosis and therapy planning. Completely automated estimation of cancer probability from the spectral signature is achieved by state-of-theart statistical classification techniques; furthermore an easyto-use interface for spectrum labeling, classifier ret...

Prostate Adenocarcinoma is one of the most commonly diagnosed cancers in the United States, with a prevalence of around 2.4 million. Patients with this disease commonly present with urinary frequency and hesitancy, nocturia, and dysuria secondary to tumor enlargement. We present the case of a 60-year-old man with multiple-site biopsy proven metastatic prostate cancer that presented with neither...

PURPOSE The indication for surgery in locally advanced prostate cancer is growing considering and long-term follow-up shows that 60-80% of patients can be free of clinical recurrence. The aim of this video is demonstrate the modifications in traditional laparoscopic surgery that permit to observe the oncological principles reproducing open surgery. MATERIALS AND METHODS A 55 years-old male pr...

The cells' ability to proliferate in response to growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations in prostate cancer, the role and expression of beta1A integrin and type 1 insulin-like growth factor receptor (IGF-IR), known to contribute to cell proliferation and transformation, were analyzed. Using small in...