Extended Hildebrand solubility approach is used to estimate the solubility of nabumetone in binary solvent systems. The solubility of nabumetone in various propylene glycol-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of nabumetone in the binary solvent, propylene glycol-water...

PURPOSE To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss. METHODS The various NLC formulations (A1-A5) were prepared and their particle size, zeta potential, viscosity, and stability were analy...

AIMS To investigate the effect of RU486 (mifepristone) on emotional disorders in chronic restraint stress-induced rats and to explore the mechanisms of that phenomenon. METHODS For this purpose, 80 healthy male Sprague Dawley rats were randomly divided into four groups: the normal group (Con group, The Con group members received no treatment, eating and drinking freely), the chronic restraint...

The reaction of the old yellow enzyme and reduced flavins with organic nitrate esters has been studied. Reduced flavins have been found to react readily with glycerin trinitrate (GTN ) (nitroglycerin) and propylene dinitrate, with rate constants at pH 7.0, 25 degrees C of 145 M(-1)s(-1) and 5.8 M(-1)s(-1), respectively. With GTN, the secondary nitrate was removed reductively 6 times faster than...

School of Marilia, São Paulo, Brazil; Flow Citometry, and; Dermatology, Medical School of Marilia, Marilia, Brazil. Background: The prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is high and its in vitro diagnostic is a challenge. The basophil activation test with determination by flow cytometry (FC), of the expression rate of CD63 molecules has been much studie...

thin bonded films have many applications in antireflection and reflection coating, insulating and conducting films and semiconductor industries. thermal conductivity is one of the most important parameter for power packaging since the thermal resistance of the interconnections is directly related to the heat removal capability and thermal management of the power package. the defects in material...