نتایج جستجو برای: promyelocytic leukemia
تعداد نتایج: 284370 فیلتر نتایج به سال:
Peripheral blood mononuclear cells from a patient with chronic myelogenous leukemia (CML), in remission, were depleted of CD8-positive T-cells and cultured with Epstein-Barr virus. Four of 20 cultures (20%) secreted human IgG antibodies selectively reactive with the cell surfaces of certain human leukemia cell lines. Three polyclonal, Epstein-Barr virus-transformed, B-cell lines were expanded a...
Tailored treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the outcome of acute promyelocytic leukemia (APL) from a uniformly fatal disease to one most curable malignant diseases in humans. Due its high efficacy, ATO/ATRA is standard first-line therapy younger adult, non-high-risk APL patients. However, early death still major issue APL, particularly ol...
According to the World Health Organization (WHO) 2016 classification, acute promyelocytic leukemia (APL) is placed in category of AML with recurrent cytogenetic abnormalities. Cytogenetic confirmation reciprocal translocation t(15:17) essential criteria for diagnosis this entity. However, these tests may have a significant time delay and it usually characteristic morphology abnormal promyelocyt...
chain reaction. Eur J Haematol 2001;67:302–8. 12. Visani G, Buonamici S, Malagola M, Isidori A, Piccaluga PP, Martinelli G, et al. Pulsed ATRA as single therapy restores long-term remission in PMLRAR -positive acute promyelocytic leukemia patients: real time quantification of minimal residual disease. A pilot study. Leukemia 2001;15:1696– 700. 13. Gallagher RE, Yeap BY, Bi W, Livak KJ, Beaubier...
Acute Promyelocytic Leukemia (APL) is a distinct subtype of myeloid leukemia that in the USA alone affects more than 3,000 individuals every year. APL is characterized by three distinct and unique features: i) the accumulation in the bone marrow of tumor cells with promyelocytic features; ii) the invariable association with specific translocations which always involve chromosome 17 and the Reti...
Background: Multidrug resistance (MDR) is one of the strategies developed by cancer cells to inhibit anticancer potential majority chemotherapeutic agents and almost results in treatment failure. Objective: This study aimed evaluate therapeutic camel milk exosomes (CME) on multidrug-resistant human acute promyelocytic leukemia HL60 (HL60/RS) investigate whether this CME could potentiate effect ...
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