The easily prepared hemilabile ligand 1-(PPh2),2-(trans-CH?CHCOPh)–C6F4 (PhPEWO-F) and other PEWO ligands are well-known promoters of C–C reductive eliminations very effective in Negishi coupli...

Signal coordinating a response by multiple RNAP holoenzymes. In Escherichia coli, the vast majority of transcription results from the RNA polymerase (RNAP) holoenzyme containing 70 (E ). However, there are six other factors that each recognize other sets of promoters, often united by common function. 32 ( ) controls heat shock promoters, 54 ( ) controls promoters for nitrogen assimilation (as w...

Class II CAP-dependent promoters, interacting with the RNAP ␣ subunit C-terminal domain (␣CTD) and facilitat-At Class I CAP-dependent promoters, interaction between the activating region and ␣CTD (and concomitant St. Louis, Missouri 63104 recruitment of RNAP to promoter DNA) appears to be the entire basis of transcription activation. Thus, at Class Summary I CAP-dependent promoters, removal of ...

We present here a computational analysis showing that sigma70 house-keeping promoters are located within zones with high densities of promoter-like signals in Escherichia coli, and we introduce strategies that allow for the correct computer prediction of sigma70 promoters. Based on 599 experimentally verified promoters of E.coli K-12, we generated and evaluated more than 200 weight matrices opt...

Senescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases vivo. Although the INK4/ARF locus is known to be essential for senescence programmes, key regulators driving p16 ARF transcription remain largely underexplored. Using siRNA screening modulators p16/pRB ARF/p53/p21 pathways deeply senescent human mammary epithelial cells (DS HMECs) fibroblasts...

Antibiotic growth promoters (AGPs) are commonly used within poultry farming to increase muscle growth. Microbial composition in the gut is known be influenced by AGP use although exact AGP-induced changes remain unclear.

Abstract Several opportunities arise for rule of law promoters: to reclaim the security discourse; explain EU enlargement through commitment law; and consequently, develop a strategy influence opponents enlargement.

Transcription is the first step in gene expression, and it is the step at which most of the regulation of expression occurs. Although sequenced prokaryotic genomes provide a wealth of information, transcriptional regulatory networks are still poorly understood using the available genomic information, largely because accurate prediction of promoters is difficult. To improve promoter recognition ...