Activated and promoter-bound heat-shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, this is facilitated by the core Mediator in Drosophila yeast. Another module, CDK8 kinase module (CKM), consisting of four subunits including MED12 CDK8, plays a negative or positive role regulation transcription; however, its involvement HSF1-mediated remains unclear. We...

The application of interactive learning multimedia is one the factors that impact process for achieving outcomes. In developing a mobile application, main principle usability. This research goal to presents usability evaluation Jawara Sains, which learn science subjects. used System Usability Scale (SUS) questionnaire measure level users’ perceived score can indicate performance effectiveness, ...

Abstract Glioblastoma targeted therapeutics have been challenging to develop due significant inter- and intra-tumoral heterogeneity. While many activated oncogenes in glioblastoma are subclonal, TERT promoter mutations commonly occur as clonal events found up 80% of IDH-wildtype glioblastomas. Given the high prevalence nature glioblastoma, telomerase is considered a promising therapeutic target...

• Self-separable H 2 fuel without forming CO x over 2D SnS/g-C 3 N 4 heterojunction. Selective redox-reactions enabled higher value-added liquid chemicals. Ultra-stable new-record efficiency in producing with low-cost catalyst. Sustainable constructive utilization of elements from alcohols. To reach Paris Agreement’s target 1.5 °C global temperature increase by 2100, low emission strategies are...

Aim. 5S ribosomal DNA (5S rDNA) represents a universal model for studying the evolution of repeated sequences in eukaryotic organisms. Taking into account that this region genome still remains almost undescribed species family Sapindaceae, we investigated molecular organization unit rDNA member family, Litchi chinensis. Methods. PCR amplification, cloning and sequencing rDNA. Results. It was fo...

cyp3a4 probably has the broadest catalytic activity of any cytochrome p450. it is a crucial task to test new drug candidates in a reliable system for their ability to induce expression of this enzyme. firstly, a total of 300 bp core distal enhancer of cyp3a4 xrem region (-7972/-7673) were amplified from human genomic dna. the pcr product was then ligated into a human secretory alkaline phosphat...

pure and zno-doped ni0.1co0.9fe2o4 catalyst were prepared by co-precipitation method and thermal decomposition in air calcinated at 400-700°c and that treated with different amounts of zinc nitrate (0.46-2.25 w% zno). x-ray powder diffractometry, scanning electron microscopy (sem) and bet analysis of nitrogen adsorption isotherms investigated the crystalline bulk structure and the surface area ...

objective: autism is a neurodevelopmental disorder characterized by difficulty in verbal and non-verbal communication, impaired social interaction, and restricted and repetitive behavior. it has been recently introduced as a multigenic disorder with significant epigenetic effects on its pathology. recently, epigenetic silencing of retinoic acid receptorrelated orphan receptor alpha (rorα) gene ...

The biosynthetic pathways of saturated and unsaturated fatty acids consist of many steps controlled by various enzymes. One of the methods for improving oil quality is to change the fatty acid profile through genetic manipulation which requires isolation and characterization of the genes and other cis-acting elements, such as the promoter, involved in fatty acid biosynthesis. b-ketoacyl-CoA syn...