Selectivity rules in organic chemistry have been inferred largely from nonaqueous environments. In contrast, enzymes operate in water, and the chemical effect of the medium change remains only partially understood. Structural characterization of the "ladder" polyether marine natural products raised a puzzle that persisted for 20 years: Although the stereochemistry of adjacent tetrahydropyran (T...

Carbonitriles and alcohols react in a Lewis acid-promoted Pinner reaction to carboxylic esters. Best results are obtained with two equivalents of trimethylsilyl triflate as Lewis acid. Good yields are achieved with primary alcohols and aliphatic or benzylic carbonitriles, but the straightforward synthesis of acrylates and benzoates starting with acrylonitrile and benzonitrile, respectively, is ...

Triisobutylaluminium-promoted rearrangement of unsaturated glycosides containing electron-donating aglycons, such as C-aryl glycosides, provides direct access to highly functionalised cyclohexane derivatives.

Role of Bacillus subtilis Error Prevention Oxidized Guanine System (GO) in 1 Counteracting Hexavalent Chromium-Promoted-Oxidative DNA Damage 2 3 4 Fernando Santos-Escobar, J. Félix Gutiérrez-Corona and Mario Pedraza-Reyes 5 6 7 Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, 8 P.O. Box 187, Guanajuato, 36050, Gto. México. 9 10 11 12 13 Running Title: Rol...

Cyclization of 1,6-diynes promoted by stoichiometric Ga(III) halides produces vinyl halides in good to excellent yields. Under acidic conditions, initially formed iodocyclization products undergo in situ Friedel-Crafts cyclizations, giving access to iodoindenopyridines. Application of the vinyl halides in cross-coupling reactions has been explored, and mechanistic aspects of the cyclization are...

would do, the University of Pittsburgh is emphasizing the importance of information technology and computer education in all aspects of the university’s life. It is natural for the Computer Science department to assume a major role in realizing the vision of the University. In fact, the support and commitment that our department is receiving from the University, in general, and FAS in par-ticul...

this research aims to understand mother’s and girl’s expectations from their spouses, and shows the difference between these two generation’s expectations. along this, by using qualitative approach and deep semi-structured interview, we studied the expectations difference among 14 mothers and 14 girls resided at tehran city’s fifth region (area).results from the research showed that women’s exp...

The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).

Saccharide oxyanions obtained by base treatment could be employed in glycosylation to give oligosaccharides with high stereo- and regioselectivities.

Vasculogenic mimicry (VM) refers to the unique capability of aggressive tumour cells to mimic the pattern of embryonic vasculogenic networks. Epithelial-mesenchymal transition (EMT) regulator slug have been implicated in the tumour invasion and metastasis of human hepatocellular carcinoma (HCC). However, the relationship between slug and VM formation is not clear. In the study, we demonstrated ...